Results 71 to 80 of about 1,201,583 (289)

A new slurry-based method of preparation of specimens of sand containing fines [PDF]

, 2007
A new method of specimen reconstitution is presented that is appropriate for element testing of sands containing either plastic or nonplastic fines. The method allows reconstitution of homogeneous, saturated specimens of sands containing fines whose ...
Carraro, JAH, Prezzi, M
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Stress-strain state of earth dam under harmonic effect [PDF]

E3S Web of Conferences, 2019
Stress-strain state of earth dams under the effect of harmonic (seismic) load from the base of the dam is numerically studied in the paper. Rock fill dam has good culvert properties and its water saturation is considered to have no effect on mechanical ...
Khusanov Bakhtiyar, Khaydarova Ozodakhon
doaj   +1 more source

Strain Effect in MgB2/Stainless Steel Superconducting Tape

, 2001
The influence of mechanical strain on the critical current (Ic) is investigated for MgB2/stainless steel (SUS316) superconducting tapes. The tapes are fabricated by using 'powder in tube' method and deformation process without any heat treatment.
Glowacki, H. Kitaguchi, H. Kumakura, K. Togano, Kitaguchi, Kitaguchi, Nagamatsu, ten Haken, ten Haken   +8 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Identification of plastic constitutive parameters at large deformations from three dimensional displacement fields [PDF]

, 2012
The aim of this paper is to provide a general procedure to extract the constitutive parameters of a plasticity model starting from displacement measurements and using the Virtual Fields Method.
A Bertram, A Germaneau, A Gorry, A Savitzky, AJ Romano, AJ Romano, AP Karafillis, B Plunkett, BK Bay, C Franck, D Banabic, D Mohr, E Verhulp, F Barlat, F Barlat, F Latourte, F Pierron, F Pierron, FA Nichols, Fabrice Pierron, G Dhondt, G Losilla, GZ Voyiadjis, H Tao, H Vegter, HP Feigenbaum, J Kajberg, KS Zhang, M Brunet, M Darrieulat, M Gates, M Grédiac, M Grédiac, M Rossi, Marco Rossi, MHH Meuwissen, N Tvergaard, O Cazacu, OC Zienkiewicz, R Fletcher, R Hill, R Hill, R Mahnken, S Atay, S Avril, S Avril, S Avril, S Avril, S Avril, S Cooreman, S Roux, T Guélon, T Wierzbicki, TS Smith, V Laws, WT Lankford, Y Bai, Y Hwang, Y Ling, YM Hwang   +59 more
core   +5 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Correlations Between Metallurgical Characterization Studies, Exploratory Mechanical Tests, and Continuum Mechanics Approaches to Constitutive Equations [PDF]

, 1983
Austenitic stainless steels, such as types 316 and 304, are widely used as pressure vessel materials in the temperature range of 425 to 650 C. Stainless steel specimens were tested to rupture at two different stress levels sigma and sigma 2 sigma 1 sigma
Moteff, J., Pugh, C. E., Swindeman, R. W.   +2 more
core   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source