Results 81 to 90 of about 1,214,562 (306)

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Finite element analysis of residual stresses in large cold-rolled thread [PDF]

, 2019
As a subproject of the DFG Research Training Group Graduiertenkolleg 2075 Modelling the constitutive evolution of building materials and structures with respect to aging (GRK 2075), the fatigue behaviour of rolled-after heat-treatment and hot-dipped ...
Jahns, Hendrik, Thiele, Klaus, Unglaub, Julian   +2 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

The Application of the Stress Function Eri for Nuclear Reactor’s Fuel Elements Strain Analysis

Механика машин, механизмов и материалов, 2010
The mathematical-mechanical models for describe steady stressstrain state of the nuclear reactors fuel pins are proposed. The possibility of the application stress function Eri for determining stress-strain state of the atomic power station's fuel pins ...
I.S. Kulikov , P.I. Shirvel'
doaj  

Identification of plastic constitutive parameters at large deformations from three dimensional displacement fields [PDF]

, 2012
The aim of this paper is to provide a general procedure to extract the constitutive parameters of a plasticity model starting from displacement measurements and using the Virtual Fields Method.
A Bertram, A Germaneau, A Gorry, A Savitzky, AJ Romano, AJ Romano, AP Karafillis, B Plunkett, BK Bay, C Franck, D Banabic, D Mohr, E Verhulp, F Barlat, F Barlat, F Latourte, F Pierron, F Pierron, FA Nichols, Fabrice Pierron, G Dhondt, G Losilla, GZ Voyiadjis, H Tao, H Vegter, HP Feigenbaum, J Kajberg, KS Zhang, M Brunet, M Darrieulat, M Gates, M Grédiac, M Grédiac, M Rossi, Marco Rossi, MHH Meuwissen, N Tvergaard, O Cazacu, OC Zienkiewicz, R Fletcher, R Hill, R Hill, R Mahnken, S Atay, S Avril, S Avril, S Avril, S Avril, S Avril, S Cooreman, S Roux, T Guélon, T Wierzbicki, TS Smith, V Laws, WT Lankford, Y Bai, Y Hwang, Y Ling, YM Hwang   +59 more
core   +5 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Modeling and Model Verification of the Stress-Strain State of Reinforced Polymer Concrete. [PDF]

Materials (Basel), 2023
Yelemessov K, Sabirova LB, Martyushev NV, Malozyomov BV, Bakhmagambetova GB, Atanova OV.   +5 more
europepmc   +1 more source