Results 91 to 100 of about 14,303,740 (385)
, 2007 Age-related immunological and endocrinological changes may have implications for resilience to stress in older adults. We hypothesise that the combination of adrenopause and immunesenescence may leave this population particularly vulnerable to the ...
Bauer +21 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
CB1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement of Cocaine Seeking in Rats [PDF]
, 2015 Rationale Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose.
Baker, David A. +6 more
core +2 more sources
FEBS Letters, EarlyView.PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley +1 more source
Frontiers in Psychiatry, 2015 Background: Common consequences of long-term psychosocial stress are fatigue and burnout. It has been suggested that burnout could be associated with hypocortisolism, thus, inability to produce sufficient amounts of cortisol.
Anna-Karin eLennartsson +5 more
doaj +1 more source
The Effects of Acute Stress Exposure on Neural Correlates of Pavlovian Conditioning with Monetary Gains and Losses [PDF]
, 2014 Pavlovian conditioning involves the association of an inherently neutral stimulus with an appetitive or aversive outcome, such that the neutral stimulus itself acquires reinforcing properties.
Delgado, Mauricio R. +2 more
core +3 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Modeling of torsion stress giant magnetoimpedance in amorphous wires with negative magnetostriction
, 2007 A model describing the influence of torsion stress on the giant magnetoimpedance in amorphous wires with negative magnetostriction is proposed. The wire impedance is found by means of the solution of Maxwell equations together with the Landau-Lifshitz ...
Antonov +39 more
core +1 more source
Rheology of Granular Materials: Dynamics in a Stress Landscape [PDF]
, 2009 We present a framework for analyzing the rheology of dense driven granular materials, based on a recent proposal of a stress-based ensemble. In this ensemble fluctuations in a granular system near jamming are controlled by a temperature-like parameter ...
Bouchaud J.-P. +3 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source