Results 41 to 50 of about 3,798,231 (274)

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Index-Based selection of Chickpea ( Cicer arietinum L.) genotypes for enhanced drought tolerance

Scientific Reports
Chickpea, a protein-rich legume grown primarily in tropical and subtropical regions, faces significant challenges due to drought stress. A field study was conducted over two years (2020-21 and 2021-22) aimed to identify chickpea genotypes that are ...
P. S. Basavaraj, Jagadish Rane, Krishna Kumar Jangid, Rohit Babar, Mahesh Kumar, Anuja Gangurde, Shweta Shinde, K. M. Boraiah, C. B. Harisha, Hanamant M. Halli, K. Sammi Reddy, M. Prabhakar   +11 more
doaj   +1 more source

Parent-led stepped care for traumatised children: parental factors that predict treatment completion and response

European Journal of Psychotraumatology, 2023
Background: Stepped care cognitive behavioural therapy for children after trauma (SC-CBT-CT; aged 7–12 years) can help to increase access to evidence-based trauma treatments for children.
Else Merete Fagermoen, Ingeborg Skjærvø, Tine K. Jensen, Silje Mørup Ormhaug   +3 more
doaj   +1 more source

Responses of any arbitrary initially stressed reference and the stress-free reference [PDF]

International Journal of Non-Linear Mechanics, 2025 p.105070
The constitutive relation for an initially stressed reference is often determined by using the response of a virtual stress-free reference. However, identifying the constitutive relation of the original stress-free body can be challenging without conducting destructive tests. This paper presents three approaches for determining the response of a stress-
arxiv   +1 more source

Theory and applications of the stress density [PDF]

, 1999
Drawing on the theory of quantum mechanical stress, we introduce the stress density in density functional theory. In analogy with the Chetty-Martin energy density, the stress density provides a spatial resolution of the contributions to the integrated macroscopic stress tensor. We give specific prescriptions for a practical and efficient implementation
arxiv   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Effect of reduced PAR on growth and photosynthetic efficiency of soybean genotypes

Journal of Agrometeorology, 2017
Soybean is an important crop, and physiologically, it is photosensitive in nature and therefore, is likely to be highly affected by the atmospheric brown clouds (ABCs) which reduce PAR (Photosynthetically Active Radiation) availability, and moisture ...
KIRAN P. BHAGAT, S.K. BAL, YOGESHWAR SINGH, S. POTEKAR, SUNAYAN SAHA, P. RATNAKUMAR, G.C. WAKCHAURE, P.S. MINHAS   +7 more
doaj   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

FEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra, Paul Weiland, Pauline Anka Plitzko, Julia Thiery, Laura Czech, Felix Willmund, Patricia Bedrunka, Gert Bange   +7 more
wiley   +1 more source

Predicting the occurrence of minor adverse events in cardiac rehabilitation using physical variables

Scientific Reports
The safety of exercise practice by individuals with cardiovascular disease is due to a good clinical evaluation to identify patients with a higher risk of adverse events, thus the study of simple variables capable of predicting the rate of events during ...
Maria Júlia Lopez Laurino, Dyovana Gomes Pinheiro, Jéssica Malek da Silva, Felipe Ribeiro, Heloisa Balotari Valente, Luiz Carlos Marques Vanderlei   +5 more
doaj   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

FEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva, Marcio Vinicius Bertacine Dias   +1 more
wiley   +1 more source