Results 71 to 80 of about 6,476,644 (264)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Research on the Strain and Stress of Powered Roof Support Construction to Limit Damage

open access: yesMachines
A powered roof support in a mining complex comprises a set of sections positioned side by side. Thus, it creates space for the mining longwall shearer and the excavated material haulage conveyor. The main role of the powered roof support is to secure the
Dawid Szurgacz
doaj   +1 more source

Optimization of Thin Shell Structures Using FSD Algorithms

open access: yesCommunications, 2012
The paper presents a theoretical and numerical study of the efficiency of the fully stress design (FSD) algorithm in the case of thin shell finite elements.
Milan Saga   +2 more
doaj   +1 more source

Compliance and stress sensitivity of spur gear teeth [PDF]

open access: yes, 1983
The magnitude and variation of tooth pair compliance with load position affects the dynamics and loading significantly, and the tooth root stressing per load varies significantly with load position.
Cornell, R. W.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Fatigue Performance of 6063-T66 Aluminum Alloy under Combined Cyclic Loading of Parent and Welded Specimens

open access: yesCommunications, 2012
The article deals with the determining of fatigue lifetime of structural materials during multiaxial cyclic loading. The aim of this investigation is to evaluate the influence on fatigue behavior of the welded aluminum alloy EN AW 6063-T66.
Peter Kopas, Milan Saga, Milan Uhricik
doaj   +1 more source

Sport psychologists’ experiences of organizational stressors [PDF]

open access: yes, 2011
This study extends stress research by exploring sport psychologists’ experiences of organizational stressors. Twelve accredited sport psychologists (6 academics and 6 practitioners) were interviewed regarding their experiences of organizational stress ...
Coombes, Matthew   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

In plane stress analysis [PDF]

open access: yes
An investigation of the blowing up of UK numerical results for the inplane stress calculations for silicon ribbon is presented. The inplane stress that exists in a thin plate is governed by two general equations of equilibrium and ...
Dillon, O. W., Jr.
core   +1 more source

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