Results 101 to 110 of about 3,120,207 (302)

Assessment of thermal stress risk in mass concrete elements: use of expedited diagrams [PDF]

Revista IBRACON de Estruturas e Materiais
Large structural elements have been commonly observed in increasingly tall buildings, employing mass concrete elements in their foundations. In these elements, the internal heat generated by the cement hydration can be decisive for the occurrence of ...
Bruno Pessoa, Carlos Britez, Sérgio Botassi, Jéssica Dantas, Mariana Carvalho, Douglas Couto, Carlos Marmorato Gomes   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A general purposed machine learning interatomic potential for Mg-Al-Si-O system suitable for Earth materials at high pressure and temperature conditions

npj Computational Materials
Accurate phase diagrams and thermodynamic properties of Earth materials are essential for advancing geophysical, geodynamical and geological studies. Apart from experiment, atomistic simulations, particularly molecular dynamics, can be used to obtain ...
Xin Zhong, Yifan Li, Timm John
doaj   +1 more source

Workability Limit Diagram at Plane Stress Condition

Advanced Technologies & Materials
Numerous experimental studies of workability limit diagrams in the domain of bulk deformation have been performed on specimens where failure occurs at the free surface, i.e., under plane stress conditions. Previous investigations of workability diagrams using compression tests on axially symmetric specimens have yielded negative values of the stress ...
Marko Vilotić, Mladomir Milutinović, Marina Rynkovskaya, Sergej Aleksandrov, Dragiša Vilotić   +4 more
openaire   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Visualizing Set Relations and Cardinalities Using Venn and Euler Diagrams [PDF]

, 2013
In medicine, genetics, criminology and various other areas, Venn and Euler diagrams are used to visualize data set relations and their cardinalities.
Micallef, Luana
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

On the expressiveness of spider diagrams and commutative star-free regular languages [PDF]

, 2013
Spider diagrams provide a visual logic to express relations between sets and their elements, extending the expressiveness of Venn diagrams. Sound and complete inference systems for spider diagrams have been developed and it is known that they are ...
Taylor, John, Delaney, Aidan, Thompson, Simon, Stapleton, Gem   +3 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Recognizing Sketches of Euler Diagrams Drawn with Ellipses [PDF]

, 2010
Euler diagrams form the basis of a number of visual languages. However, the existing tool support for creating Euler diagrams is limited to generic diagram editing software that uses mouse and keyboard interfaces.
Rodgers, Peter, Plimmer, Beryl, Delaney, Aidan, Stapleton, Gem   +3 more
core