Results 101 to 110 of about 5,046,540 (331)
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Utilisation of the method of stress limit for designing the motion screw dimensions
Research in Agricultural Engineering, 2008 A design of the motion screw using the method of stress limit is described. Further general formulas are induced to design such kind of screws, applied to an example of 11500 (EN ISO E295) steel made screw, strained by static operational force.
D. Herák +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
STRENGTH OF COMPOSITE YARN UNDER BIAXIAL LOADING
Acta Polytechnica CTU Proceedings, 2018 The present paper is concerned with two types of periodic unit cell of composite yarn with different geometry but the same material properties. Their macroscopic response under tensile and compressive loading in the transverse direction and their ...
Soňa Valentová +3 more
doaj +1 more source
Viscoelastic Moment-Curvature Diagrams
, 1987 In this paper, a computational viscoelastic analysis method of sections in reinforced concrete is presented. This study examines the stress-strain history in the interval of time considered.
S. COGNINI +3 more
core
, 2018 Herein, we study stress–strain diagrams of soft biological materials such as animal skin, muscles, and arteries by Finsler geometry (FG) modeling.
Swapan Ghosh +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Fatigue strength and durability analysis by normalised equivalent stress functionals
, 2003 Generalised fatigue durability diagrams are considered for a material under multi-axial loading given by a (non-regularly) oscillating function of time.
Mikhailov, SE +3 more
core
Mathematical modeling and simulations for large-strain J-shaped diagrams of soft biological tissues
, 2018 Herein, we study stress-strain diagrams of soft biological tissues such as animal skin, muscles and arteries by Finsler geometry (FG) modeling. The stress-strain diagram of these biological materials is always J-shaped and is composed of toe, heel ...
H. Koibuchi, S. Ghosh, K. Mitsuhashi
core +1 more source