Results 91 to 100 of about 3,120,207 (302)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Recognising Sketches of Euler Diagrams Augmented with Graphs [PDF]

, 2011
Euler diagrams form the basis of many visual languages. Such languages are formed by augmenting Euler diagrams with graphs or shading. However, tool support for creating augmented Euler diagrams is generally limited to generic diagram editing software ...
Rodgers, Peter, Plimmer, Beryl, Delaney, Aidan, Plimmer, B., Stapleton, Gem, Rodgers, P.   +5 more
core  

Embedding wellformed Euler diagrams [PDF]

, 2008
Euler diagrams are collections of labelled closed curves. They are often used to represent information about the relationship between sets and, as such, they have numerous applications including: visualizing biological data, diagrammatic logics, and ...
Andrew Fish, Zhang, Leishi, Rodgers, Peter, Fish, Andrew, Fish, Andrew; id_orcid, Gem Stapleton, Stapleton, Gem, Leishi Zhang, Peter Rodgers   +8 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Calculation of composite elements of slabs in buildings, structures and fragments of spans of bridges

MATEC Web of Conferences, 2018
The calculation consists of two stages. The first one begins with the definition of their class, bearing capacity at temperature of 20 °C, according to EN 1992-1-1.
Fomin Stanislav, Izbash Yuriy, Butenko Serhii, Iakymenko Maryna, Spirande Karina   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Extended Abstract: Force-Directed Layout for Euler Diagrams [PDF]

, 2009
Euler diagrams are the only diagrams that intuitively represent containment, intersection and exclusion of data, but none of the current automatic diagram layout techniques produce good layouts in a reasonable time.
Rodgers, Peter, Micallef, Luana
core  

Elasticidade, plasticidade, histerese... e ondas

Revista Brasileira de Ensino de Física
Neste artigo é descrito um experimento que permite estudar as propriedades mecânicas de fios sob tração. O experimento requer um monocórdio, no qual o fio é esticado e tangido, um microcomputador com placa de som e um software para análise espectral do ...
Luiz André Mützenberg, Eliane Angela Veit, Fernando Lang da Silveira   +2 more
doaj