Results 71 to 80 of about 5,046,540 (331)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A stress function for 3D frames

, 2017
This paper generalises Rankine diagrams for 3D trusses to be applicable to 3D frames. Rankine diagrams are a graphical representation of a state of self-stress in a 3D truss, with the area of reciprocal polygons representing the axial force in their ...
McRobie, FA, ,, Williams, CJK
core   +2 more sources

Some Approaches to Quantitative Classification of Plastic Deformation Processes Based on the Parameters of Their Stress–Strain State Determined by Simulation Modeling

Metals
The article discusses the methods for classifying processes for testing and processing metals by plastic deformation, based on the characteristics of their stress–strain state.
Valentin Kamburov, Rayna Dimitrova
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Universality of synergetics laws. V. Stress–strain diagrams

, 2014
Предложена синергетическая модель деформированного состояния упругопластической среды. Продемонстрирована ее адекватность экспериментальным данным при описании истинных и инженерных диаграмм напряжение–деформацияЗапропоновано синергетичну модель ...
Терехов, С.В., Саяпин, В.Н.   +1 more
core   +1 more source

MODELING OF TEAMWORK OF CONSTRUCTION AND THE BASETAKING INTO ACCOUNT CONSTRUCTION ESCALATING

Structural Mechanics of Engineering Constructions and Buildings, 2011
The model "design-foundation-basis" in the form of the two-layer beam which bottom layer corresponds to the foundation, and top - designs with the corresponding resulted characteristics are developed.
V I Andreev, E V Barmenkova, A V Matveyeva   +2 more
doaj  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Deformation-strength model application at the determining of stress-strain state of reinforced concrete structures

Trudy Odesskogo Politehničeskogo Universiteta, 2017
The work considers the possibility and expediency of deformation-strength model applica-tion in the study of stress-strain state of reinforced concrete structures.
Karpiuk V. M. , Kostiuk А. І. , Somina Ya. А. , Danilenko D. S.   +3 more
doaj   +1 more source

Diagrams of statistical strength criterion for reinforced composite materials

, 2021
The model of a plate brittle material reinforced with randomly sized and placed rigid rectilinear inclusions that do not interact with each other is considered. The geometric parameters of inclusions (length and orientation) are statistically independent
Roman Kvit, Tetyana Salo, Kvit, Roman, Salo, Tetyana   +3 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source