Results 81 to 90 of about 5,046,540 (331)

Calculation of composite elements of slabs in buildings, structures and fragments of spans of bridges

MATEC Web of Conferences, 2018
The calculation consists of two stages. The first one begins with the definition of their class, bearing capacity at temperature of 20 °C, according to EN 1992-1-1.
Fomin Stanislav, Izbash Yuriy, Butenko Serhii, Iakymenko Maryna, Spirande Karina   +4 more
doaj   +1 more source

Assessment of thermal stress risk in mass concrete elements: use of expedited diagrams [PDF]

Revista IBRACON de Estruturas e Materiais
Large structural elements have been commonly observed in increasingly tall buildings, employing mass concrete elements in their foundations. In these elements, the internal heat generated by the cement hydration can be decisive for the occurrence of ...
Bruno Pessoa, Carlos Britez, Sérgio Botassi, Jéssica Dantas, Mariana Carvalho, Douglas Couto, Carlos Marmorato Gomes   +6 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Fracture–Mechanical Assessment of the Effect of Defects on the Fatigue Lifetime and Limit in Cast and Additively Manufactured Aluminum–Silicon Alloys from HCF to VHCF Regime

Metals, 2020
Aluminum–silicon alloys are commonly used in die-cast and additively manufactured (AM) light-weight components due to their good processability and high strength-to-weight ratio.
Jochen Tenkamp, Mustafa Awd, Shafaqat Siddique, Peter Starke, Frank Walther   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

On a Stress-Strain Diagram of Repeated Load Test

The Journal of the Japan Institute of Metals, 1937
On a stress-strain diagram obtained by repeated load tests, the following conclusions were drawn:- (1). Mechanical properties of test materials, such as yielding point, breaking stress, etc. can not directly be determined by loaddeformation diagram or an outer moment-angle diagram as in the case of statical test. (2).
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Elasticidade, plasticidade, histerese... e ondas

Revista Brasileira de Ensino de Física
Neste artigo é descrito um experimento que permite estudar as propriedades mecânicas de fios sob tração. O experimento requer um monocórdio, no qual o fio é esticado e tangido, um microcomputador com placa de som e um software para análise espectral do ...
Luiz André Mützenberg, Eliane Angela Veit, Fernando Lang da Silveira   +2 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

A general purposed machine learning interatomic potential for Mg-Al-Si-O system suitable for Earth materials at high pressure and temperature conditions

npj Computational Materials
Accurate phase diagrams and thermodynamic properties of Earth materials are essential for advancing geophysical, geodynamical and geological studies. Apart from experiment, atomistic simulations, particularly molecular dynamics, can be used to obtain ...
Xin Zhong, Yifan Li, Timm John
doaj   +1 more source