Results 91 to 100 of about 8,615,862 (293)

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology

, 2014
This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and clinical management, including recognition, acute ...
den Boer, J.A., Fineberg, N.A., Bandelow, B., Davies, S., Nutt, David J, Wee, N. van der, Fineberg, Naomi, Scott, Jan, O'Neill, C., Anderson, I.M., Nutt, D.J., O’Neill, C., Scott, J., Allgulander, Christer, Christmas, D.M., Christmas, David M, Fineberg, N., Davies, Simon, Allgulander, C., Anderson, Ian M., McCrone, P., Wittchen, H-U, Christmas, David M., van der Wee, N., Anderson, Ian M, Malizia, A., Nutt, David J., O'Neill, Catherine, Baldwin, D.S., Lidbetter, N., Lidbetter, Nicky, Bandelow, Borwin, Nabarro, Daniel, Malizia, Andrea, McCrone, Paul, van der Wee, Nic, Wittchen, Hans-Ulrich, Baldwin, David S., Baldwin, David S, den Boer, Johan A, Nabarro, D., Boer, J.A. den, Wittchen, H.U., Fineberg, Naomi A., den Boer, Johan A.   +44 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Interreality in the Management of Psychological Stress: a Clinical Scenario [PDF]

, 2010
The term “psychological stress” describes a situation in which a subject perceives that environmental demands tax or exceed his or her adaptive capacity.
RIVA, Giuseppe
core   +1 more source

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Neuroepigenetics of Post-Traumatic Stress Disorder [PDF]

, 2018
While diagnosis of PTSD is based on behavioral symptom clusters that are most directly associated with brain function, epigenetic studies of PTSD in humans to date have been limited to peripheral tissues. Animal models of PTSD have been key for understanding the epigenetic alterations in the brain most directly relevant to endophenotypes of PTSD, in ...
Grace S, Kim, Alicia K, Smith, Caroline M, Nievergelt, Monica, Uddin   +3 more
openaire   +2 more sources

Post-typhoon prevalence of post-traumatic stress disorder, major depressive disorder, panic disorder, and generalized anxiety disorder in a Vietnamese sample [PDF]

, 2009
In 2006, typhoon Xangsane disrupted a multiagency health needs study of 4,982 individuals in Vietnam. Following this disaster, 798 of the original participants were reinterviewed to determine prevalence and risk factors associated with posttraumatic ...
Thach, T.D., Gaboury, M.T., Kilpatrick, D.G., Richardson, L.K., Trung, L.T., Tam, N.T., Acierno, R., Tran, T.L., Gros, D.F., Galea, S., Ha, T.T., Amstadter, A.B., Tuan, T., Buoi, L.T.   +13 more
core  

Traumatic events and physical health in a New Zealand community sample

, 2002
Traumatic event exposure and physical health were examined in a community-residing sample of 1,500 New Zealand adults. Half (51%) reported past traumatic event exposure, 9% reported recent (past 12 months) trauma exposure, and 40% reported no exposure ...
Flett RA, Kazantzis N, Long NR, Millar M, MacDonald C   +4 more
core   +1 more source

A randomised controlled pilot study: the effectiveness of narrative exposure therapy with adult survivors of the Sichuan earthquake [PDF]

, 2013
Background: Post-Traumatic Stress Disorder (PTSD) is a common psychological reaction after large-scale natural disasters. Given the number of people involved and shortage of resources in any major disaster, brief, pragmatic and easily trainable ...
Hunt, Nigel, Cox, Tom, Nigel Hunt, Zang, Y., Cox Tom, Yinyin Zang, Tom Cox, Hunt Nigel, Zang, Yinyin, Zang Yinyin, Hunt, N.   +10 more
core   +2 more sources