Results 91 to 100 of about 4,796,702 (301)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Exercise is medicine for patients with major depressive disorders : but only if the “pill” is taken!

Neuropsychiatric Disease and Treatment, 2016
Markus Gerber,1 Edith Holsboer-Trachsler,2 Uwe Pühse,3 Serge Brand1,2 1Department of Sport, Exercise and Health, Division of Sport and Psychosocial Health, University of Basel, 2Center for Affective, Stress and Sleep Disorders, Psychiatric ...
Gerber M, Holsboer-Trachsler E, Pühse U, Brand S   +3 more
doaj  

Etiopathogenetical and clinical relation of stress and depression [PDF]

, 2014
Practically every aspect of our person may be under stress, and its effects are partially mediated by corticosteroid hormones, which affect the nervous system. Stress can directly induce dysfunction and pathological alterations in brain structure.
Kostencka Alicja, Cichacz-Kwiatkowska Beata, Sekita-Krzak Joanna   +2 more
core   +1 more source

Oxidative Stress and Antioxidants in Neurodegenerative Disorders

, 2023
Neurodegenerative disorders constitute a substantial proportion of neurological diseases with significant public health importance. The pathophysiology of neurodegenerative diseases is characterized by a complex interplay of various general and disease ...
R. M. Damian Holsinger, Edward O. Olufunmilayo, Michelle B. Gerke-Duncan   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Prevalence and prognosis of stress disorders: a review of the epidemiologic literature

, 2017
Jaimie L Gradus1–4 1National Center for PTSD, VA Boston Healthcare System, 2Department of Psychiatry, Boston University School of Medicine, 3Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA; 4Department of ...
Gradus JL
core  

The contribution of work and non-work stressors to common mental disorders in the 2007 Adult Psychiatric Morbidity Survey. [PDF]

, 2011
Evidence for an effect of work stressors on common mental disorders (CMD) has increased over the past decade. However, studies have not considered whether the effects of work stressors on CMD remain after taking co-occurring non-work stressors into ...
Jenkins, R., C. Pike, McManus, S., Brugha, T, Bebbington, Paul, Bebbington, P., Weich, S., R. Jenkins, Pike, C, T. Brugha, S. Weich, J. Harris, Weich, S, Clark, C., McManus, Sally, Meltzer, H, Meltzer, H., C. Clark, Stansfeld, Stephen, S. Stansfeld, Brugha, T. S. (Traolach S.), Brugha, T., Meltzer, Howard, McManus, S, Harris, J., Jenkins, Rachel, S. McManus, Jenkins, R, Harris, J, Bebbington, P. E., Stansfeld, S, P. Bebbington, Clark, C, Pike, C., Bebbington, P, H. Meltzer, Stansfeld, S., Clarke, C., Weich, Scott   +38 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction

, 2020
Oxidative stress based on mitochondrial dysfunction is assumed to be the principal molecular mechanism for the pathogenesis of many neurodegenerative disorders.
Hidehiko Okazawa, Makoto Yoneda, Yasunari Nakamoto, Masamichi Ikawa   +3 more
core   +1 more source