Results 111 to 120 of about 4,796,702 (301)

Influence of parenting on the stress response and the development of stress-related disorders [PDF]

, 2022
openUna risposta disadattiva allo stress è alla base di molti disturbi psicologici, tra cui depressione e PTSD. La risposta allo stress e i sistemi biologici ad essa sottostanti si sviluppano in età precoce, in questa tesi si vuole analizzare il ruolo ...
BUSELLU, MARTINA
core  

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Neural circuits in anxiety and stress disorders: a focused review

, 2015
Elizabeth R Duval, Arash Javanbakht, Israel LiberzonDepartment of Psychiatry, University of Michigan Health System, Ann Arbor, MI, USAAbstract: Anxiety and stress disorders are among the most prevalent neuropsychiatric disorders.
Duval ER, Javanbakht A, Liberzon I
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Oxytocin and Stress-related Disorders: Neurobiological Mechanisms and Treatment Opportunities

, 2017
Novel pharmacotherapies that improve outcomes for individuals with stress-related psychiatric disorders are needed. The neurohormone oxytocin (OT) is a promising candidate given its influence on the social-emotional brain.
Allington, Casey E., Miranda Olff, Sippel, Lauren M., Olff, Miranda, Mayes, Linda C., Linda C. Mayes, Lauren M. Sippel, Pietrzak, Robert H., Harpaz-Rotem, Ilan, Robert H. Pietrzak, Casey E. Allington, Ilan Harpaz-Rotem   +11 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Stress in Children with Pervasive Developmental Disorders [PDF]

, 2011
The purpose of this study is to examine urinary 17-hydroxycorticosteroid (OHCS) excretion as a measureof stress response in controls and in children with pervasive developmental disorders (PDDs) accompaniedby mental retardation( MR, intelligence quotient[
Suzuki, Naomitsu
core