Results 121 to 130 of about 4,796,702 (301)

Early Life Stress, Mood, and Anxiety Disorders

, 2017
Early life stress has been shown to exert profound short- and long-term effects on human physiology both in the central nervous system and peripherally. Early life stress has demonstrated clear association with many psychiatric disorders including major ...
Shariful A. Syed, Nemeroff, Charles B, Syed, Shariful A, Charles B. Nemeroff   +3 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Synergy of rehabilitation for stress-related disorders and ARIs in school-age children under the war condition in Ukraine

Zdorovʹe Rebenka
Background. A significant part of the children’s population of Ukraine suffers from stress-related disorders, which lead to serious complications and somatic diseases, including an increased incidence of acute respiratory pathology, and create a global ...
I.O. Mityuryayeva-Kornijko, Ie.A. Burlaka, T.D. Klets, O.A. Panchenko, A.V. Kabantseva, E.S. Sukhodolska   +5 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Editorial: Psychometrics in psychiatry 2022: anxiety and stress disorders. [PDF]

Front Psychiatry, 2023
Duan W, Wang J, Trindade IA, Zsido AN.
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Investigating the effect of guided self-help through social networks on post-traumatic stress disorder symptoms and resilience of mothers with children suffering from febrile seizures

Journal of Education and Health Promotion
BACKGROUND: Seizure caused by fever is the most common seizure disorder in childhood, which occurs in children between 6 months and 5 years, with a temperature above 38 degrees Celsius.
Iman Seyfi, Zohreh Karimi, Abdolkarim Ghadimi Moghadam, Cirruse Salehnesab, Mohammad Malekzadeh   +4 more
doaj   +1 more source

Mindfulness-based stress reduction intervention in a sample of pregnant women in a rural area. [PDF]

, 2012
In this study, nine pregnant women in a rural area were assessed for a range of affective and mood disorders, as well as for coping self-efficacy and use of mindfulness in daily life.
Williams, Stephen Gordon
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source