Results 101 to 110 of about 4,796,702 (301)

Stress reactivity in heroin dependence [PDF]

, 2015
Background: Heroin dependence is a chronic relapsing disorder characterized by a compulsion to seek and use heroin despite the negative consequences. In addition to the diagnostic criteria, heroin dependence is associated with an altered function of the ...
Gerber, Hana
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Evaluation of Circulating Levels of ICAM-1 in Obstructive Sleep Apnea (OSA) Adults: Systematic Review, Meta-Analysis, and Trial Sequential Analysis of Link Between OSA and Cardiovascular Disease

Life
Obstructive sleep apnea (OSA) is a common condition characterized by repeated airway collapses during sleep, contributing to oxygen desaturation, arousals, and significant cardiovascular complications.
Mohammad Moslem Imani, Arya Imani, Masoud Sadeghi, Annette Beatrix Brühl, Serge Brand   +4 more
doaj   +1 more source

Rethinking medical school curriculum: An exploratory study of medical student mental health in a nontraditional program

Journal of Mental Health and Human Behaviour, 2019
Context: Medical student mental health has been studied extensively, yet little is known about students in nontraditional medical school programs. Aims: The goal of this study was to assess the frequency of symptoms of mental illness in the first, second,
Lindsey N Teal, Krucial K Styslinger, Steven H Kelder, Freya Spielberg   +3 more
doaj   +1 more source

Latent class analysis of co-morbidity in the Adult Psychiatric Morbidity Survey in England 2007 : implications for DSM-5 and ICD-11 [PDF]

, 2011
Background. Psychiatric co-morbidity is complex and ubiquitous. Our aim was to describe the extent, nature and patterning of psychiatric co-morbidity within a representative sample of the adult population of England, using latent class analysis ...
Exeter, D., O. McBride, D. Exeter, McManus, Sally, McBride, O., Hussey, D., S. McManus, D. Hussey, Weich, Scott, Brugha, T. S. (Traolach S.), S. Weich, T. Brugha   +11 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A Pilot Study of the Effects of Mindfulness-Based Stress Reduction on Post-traumatic Stress Disorder Symptoms and Brain Response to Traumatic Reminders of Combat in Operation Enduring Freedom/Operation Iraqi Freedom Combat Veterans with Post-traumatic Stress Disorder

Frontiers in Psychiatry, 2017
ObjectiveBrain imaging studies in patients with post-traumatic stress disorder (PTSD) have implicated a circuitry of brain regions including the medial prefrontal cortex, amygdala, hippocampus, parietal cortex, and insula.
James Douglas Bremner, James Douglas Bremner, James Douglas Bremner, James Douglas Bremner, James Douglas Bremner, Sanskriti Mishra, Carolina Campanella, Majid Shah, Nicole Kasher, Sarah Evans, Negar Fani, Amit Jasvant Shah, Amit Jasvant Shah, Collin Reiff, Lori L. Davis, Lori L. Davis, Lori L. Davis, Viola Vaccarino, Viola Vaccarino, James Carmody   +19 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Physical activity and self-esteem: testing direct and indirect relationships associated with psychological and physical mechanisms

Neuropsychiatric Disease and Treatment, 2016
Seyed Hojjat Zamani Sani,1 Zahra Fathirezaie,1 Serge Brand,2 Uwe Pühse,3 Edith Holsboer-Trachsler,2 Markus Gerber,3 Siavash Talepasand4 1Department of Motor Behavior, Faculty of Physical Education and Sport Science, University of Tabriz, Tabriz,
Zamani Sani SH, Fathirezaie Z, Brand S, Pühse U, Holsboer-Trachsler E, Gerber M, Talepasand S   +6 more
doaj  

Changes in mindfulness facets across yoga, CBT and stress education in individuals with generalized anxiety disorder

Journal of Mood and Anxiety Disorders
Improving mindfulness is an important treatment target for generalized anxiety disorder (GAD). However, less is known about how different treatments impact specific aspects of mindfulness.
Danielle Moskow Diamond, David Rosenfield, Nikki Kaiser, Amanda W. Baker, Elizabeth A. Hoge, Sat Bir S. Khalsa, Stefan G. Hofmann, Naomi M. Simon   +7 more
doaj   +1 more source