Results 121 to 130 of about 3,599,226 (303)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Dizhen xuebao利用双差定位法对2010年8月1日至2014年12月31日福建仙游地区中国地震台网中心记录到的地震群进行重定位，并采用P波初动的方法求解出该震群的159个震源机制解，显示该震群的震源机制解结果与背景构造应力场表现明显不一致。为了进一步探究差异性存在的原因，将得到的震群震源机制解结果分区域和分深度求解应力场，结果显示：金钟水库的东南部附近应力方向更远离背景构造应力方向，并且应力形因子小于0.5，中间轴呈现为拉张应力；随着深度的增加，应力场的方向也更接近背景构造应力场的方向。此外 ...
Hailin Yu +4 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Numerical Simulation of Stress Field in Laser Cladded Gate of Flat Gate Valve
Shiyou jixie, 2016 As a key member of gate valve, the abrasion and corrosion of the gate can severely hamper the application of flat gate valve in the oil industry.Based on thermal elastoplastic theory, laser cladding of the gate with Ni-based alloy was simulated by means ...
Cai Chunbo +3 more
doaj
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Design method and application of temporary plugging by fiber and diverting acid fracturing
Youqicang pingjia yu kaifa, 2019 In order to solve the problem of quantitative design of fiber in fiber temporary plugging and diverting acid fracturing, a total stress field model considering the initial artificial fracture, adjacent well artificial fracture, pore pressure change ...
Zhifeng LUO +5 more
doaj
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source