Results 111 to 120 of about 3,599,226 (303)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

利用S波分裂分析2022年泸定MS6.8地震震源区上地壳各向异性

Dizhen xuebao
利用四川省地震局布设的流动台站及区域固定台网记录的2022年泸定MS6.8地震序列波形数据，进行了近震S波分裂的计算分析，研究了各台站上地壳各向异性参数的空间分布和随时间的趋势性变化特征，以及S波分裂的关键参数—快S波偏振方向和慢S波时间延迟—的时空变化。结果显示，快波偏振方向和慢波时间延迟在空间上的分布呈现明显的分区特征，并且随时间的推移表现出一定的趋势性变化，这表明上地壳各向异性不仅受控于空间位置，还受到随时间变化的应力场的影响。鲜水河断裂带上的台站L5512 ...
Texi Deng, Tuo Zheng, Fei Rao, Xiaoping Fan, Dahu Li, Peng Zhang, Wei Fu   +6 more
doaj   +1 more source

Dynamical Backreaction in Robertson-Walker Spacetime

, 2011
The treatment of a quantized field in a curved spacetime requires the study of backreaction of the field on the spacetime via the semiclassical Einstein equation. We consider a free scalar field in spatially flat Robertson-Walker space time.
BENJAMIN ELTZNER, Dappiaggi C., Gackstatter F., HANNO GOTTSCHALK, Wald R. M., Weinberg S.   +5 more
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Surrogate modelling of thermal and residual stress fields in cold-spray additive manufacturing using machine learning

Virtual and Physical Prototyping
In cold spray additive manufacturing, temperature and residual stress evolution significantly affect product quality and service life. Conventional finite element (FE) simulations provide predictions but are computationally expensive for large-scale ...
Chunyang Xia, Scott Julien, Salih Duran, Elizabeth Chang-Davidson, Santanu Paul, Sinan Müftü   +5 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

As a researcher engaging in the field of oxidative stress

Journal of Clinical Biochemistry and Nutrition, 2011
The awful earthquake that attacked Northeast part of Japan on 11th March 2011 caused a massive tsunami to surge against the coastal place at Kanto and Tohoku area. Besides, it ran over the serious damage of the Fukushima Daiichi Nuclear Power Plant located at the coastal place of north Kanto area.
openaire   +3 more sources

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source