Results 41 to 50 of about 967,721 (269)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Characterization of the Solution of the Seismic Source Mechanism in Southeastern Sichuan

Applied Sciences
Southeastern Sichuan has witnessed intensified seismic swarm activity since 2016, including events exceeding historical peak ground accelerations.
Min Zhao, Yuping Qi, Feng Long, Liyuan Peng, Chang He, Di Wang, Xiyang Ran   +6 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Impact of well placement and flow rate on production efficiency and stress field in the fractured geothermal reservoirs

Deep Underground Science and Engineering
Geothermal energy has gained wide attention as a renewable alternative for mitigating greenhouse gas emissions. The advancements in enhanced geothermal system technology have enabled the exploitation of previously inaccessible geothermal resources ...
Xinghui Wu, Meifeng Cai, Xu Wu, Ketong Zhang, Ziqing Yin, Yu Zhu   +5 more
doaj   +1 more source

Evolution of structural characteristics with multistage stress fields in the Sikeshu Sag, Junggar Basin

地质科技通报
Objective The Sikeshu Sag of the southern Junggar Basin is tectonically located in the western thrust belt of the North Tianshan Mountains. The basin has undergone multiple stages and multidirectional tectonic movements since the Palaeozoic.
Honghui GUO, Xinming HE, Lintao ZHU, Jianwei FENG, He DU, Junxiao QU   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Subparticle stress fields in granular solids [PDF]

Physical Review E, 2009
We rely on the lattice element method to simulate and analyze the stress fields at subparticle scales in two-dimensional granular solids composed of particles of variable stiffness together with an interstitial matrix of variable volume fraction. We find that the contact force distributions as approached from the subscale stresses are similar to those ...
Topin, Vincent, Radjai, Farhang, Delenne, Jean-Yves   +2 more
openaire   +3 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source