Results 51 to 60 of about 10,570,709 (289)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Characterization of the Solution of the Seismic Source Mechanism in Southeastern Sichuan

Applied Sciences
Southeastern Sichuan has witnessed intensified seismic swarm activity since 2016, including events exceeding historical peak ground accelerations.
Min Zhao, Yuping Qi, Feng Long, Liyuan Peng, Chang He, Di Wang, Xiyang Ran   +6 more
doaj   +1 more source

SPECIALIZED MAPPING OF CRUSTAL FAULT ZONES. PART 1: BASIC THEORETICAL CONCEPTS AND PRINCIPLES

Геодинамика и тектонофизика, 2015
Long-term studies of shear zones have included collection of data on fractures showing no indication of displacement which are termed as 'blank' fractures.
K. Zh. Seminsky
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Impact of well placement and flow rate on production efficiency and stress field in the fractured geothermal reservoirs

Deep Underground Science and Engineering
Geothermal energy has gained wide attention as a renewable alternative for mitigating greenhouse gas emissions. The advancements in enhanced geothermal system technology have enabled the exploitation of previously inaccessible geothermal resources ...
Xinghui Wu, Meifeng Cai, Xu Wu, Ketong Zhang, Ziqing Yin, Yu Zhu   +5 more
doaj   +1 more source

Evolution of structural characteristics with multistage stress fields in the Sikeshu Sag, Junggar Basin

地质科技通报
Objective The Sikeshu Sag of the southern Junggar Basin is tectonically located in the western thrust belt of the North Tianshan Mountains. The basin has undergone multiple stages and multidirectional tectonic movements since the Palaeozoic.
Honghui GUO, Xinming HE, Lintao ZHU, Jianwei FENG, He DU, Junxiao QU   +5 more
doaj   +1 more source

The evolution of the crustal stress state of the Catoca kimberlite pipe area (northeastern Angola)

Геодинамика и тектонофизика, 2018
This paper presents the first results of the geostructural and tectonophysical studies of the crustal stress state in the Catoca kimberlite pipe area at the southwestern flank of the Kasai Shield in the northeasternAngola. In the evolution of the crustal
O. V. Lunina, A. S. Gladkov, D. P. Gladkochub, F. João, M. A. Karpenko, J. T. Félix, D. A. Koshkarev, E. V. Sklyarov   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source