Results 71 to 80 of about 32,771 (219)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Architecture of the upper crust along the WARR deep seismic profile SHIELD’21 across Ukraine based on seismic and geological data

Геофизический журнал
For the first time a seismic image of the East-European Craton upper crust between the Carpathians and the Dnieper-Donets Basin is presented, based on the finite-difference reflection/refraction migration processing of the SHIELD’21 deep profile results
A.V. Murovska, O.O. Verpakhovska, V.I. Starostenko, T.P. Yegorova, T. Janik, P. Aleksandrowski, S.V. Mychak, V.I. Alokhin   +7 more
doaj   +1 more source

Regularity of three fields evolution of hydraulic fracturing process in coal seam

Gong-kuang zidonghua, 2016
Numerical simulation was conducted for hydraulic fracturing process in coal seam according to solid-liquid coupling equations and Mohr-Coulomb principle.
XU Zhaoyong, SONG Dazhao, QIU Liming, WANG Enyuan, MA Yafei, HE Junjiang   +5 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

利用S波分裂分析2022年泸定MS6.8地震震源区上地壳各向异性

Dizhen xuebao
利用四川省地震局布设的流动台站及区域固定台网记录的2022年泸定MS6.8地震序列波形数据，进行了近震S波分裂的计算分析，研究了各台站上地壳各向异性参数的空间分布和随时间的趋势性变化特征，以及S波分裂的关键参数—快S波偏振方向和慢S波时间延迟—的时空变化。结果显示，快波偏振方向和慢波时间延迟在空间上的分布呈现明显的分区特征，并且随时间的推移表现出一定的趋势性变化，这表明上地壳各向异性不仅受控于空间位置，还受到随时间变化的应力场的影响。鲜水河断裂带上的台站L5512 ...
Texi Deng, Tuo Zheng, Fei Rao, Xiaoping Fan, Dahu Li, Peng Zhang, Wei Fu   +6 more
doaj   +1 more source

Determining the stress field in active volcanoes using focal mechanisms

Frontiers in Earth Science, 2016
Stress inversion of seismological datasets became an essential tool to retrieve the stress field of active tectonics and volcanic areas. In particular, in volcanic areas, it is able to put constrains on volcano-tectonics and in general in a better ...
Bruno Massa, Bruno Massa, Luca D'Auria, Luca D'Auria, Elena Cristiano, Ada De Matteo   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stress Field Distribution and Deformation Law of Large Deformation Tunnel Excavation in Soft Rock Mass

Applied Sciences, 2019
The problem of large deformation is very prominent in deep-buried tunnel excavation in soft rock, which brings serious potential safety hazards and economic losses to projects.
Heng Zhang, Liang Chen, Yimo Zhu, Zelin Zhou, Shougen Chen   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source