Results 61 to 70 of about 967,721 (269)
Dizhen xuebao, 2019 利用区域应力张量阻尼方法，使用南北地震带及其邻近区域2009年1月—2017年8月466次ML≥3.5地震的震源机制解，及1976年1月—2017年8月GCMT公布的259次M≥4.5地震的震源机制解，反演得到研究区1.0°×1.0°网格大小区域的构造应力场。应力场空间分布特征显示，南北地震带作为青藏高原的东边界，由于所处动力环境复杂，其内部最大主应力方向具有明显的空间差异性。这种差异主要表现为：南北地震带北段最大主应力方向为NE向；南北地震带中段及周边除龙门山断裂带NE段最大主应力为NW-NNW向外 ...
Zijian Cui +3 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Regional stress field of the Indian Plate
Geophysical Research Letters, 1985 We have calculated the regional stress field in the Indian plate, implementing dependence of slab pull and ridge push on the age of the oceanic lithosphere in the finite element procedure. The high level of the calculated stress field (order of a few kbar) and the dominance of compression in the plate are consequences of the unique dynamic situation of
Cloetingh, Sierd, Wortel, Rinus
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
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Геодинамика и тектонофизика, 2015 In the Earth's lithosphere, wavy alternation of positive and negative heterochronous structures is revealed; such structures are variable in ranks and separated by vergence zones of fractures and folds.
Tatiana Yu. Tveretinova
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Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
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The Journal of Engineering, 2015 Laser Shock Peening is a fatigue enhancement treatment using laser energy to induce compressive Residual Stresses (RS) in the outer layers of metallic components.
M. Sticchi +7 more
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
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Applied SciencesIn tunnel blasting, an analytical solution for dynamic stress in the surrounding rock of adjacent tunnels is critical for dynamic response analysis, mechanical evaluations, and crack propagation control.
Tao Luo +6 more
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Numerical study of the influence of seepage force on the stress field around a vertical wellbore
Engineering Applications of Computational Fluid Mechanics, 2020 Fluid seepage into rock pores not only generates poroelastic stress but also exerts seepage force on the rock skeleton. However, since the mechanism of the effect of seepage force on the stress field around the wellbore is not clear, conventional methods
Desheng Zhou +7 more
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