Results 91 to 100 of about 760,552 (308)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Numerical and experimental study of stress-field-driven TPMS hybrid-gradient SLM lattice for impact cushioning

Journal of Materials Research and Technology
The hybrid TPMS lattice structure is designed to buffer severe impacts and large overloads experienced by high-dynamic systems. This study analyzes the energy absorption requirements of buffering systems in breech pressure launch equipment.
Sining Lv, Yichen Chai, Hengzhen Feng, Wenzhong Lou, Chuan Xiao, Shiyi Li   +5 more
doaj   +1 more source

Nonlinear superhorizon perturbations of non-canonical scalar field

, 2008
We develop a theory of non-linear cosmological perturbations at superhorizon scales for a scalar field with a Lagrangian of the form $P(X,\phi)$, where $X=-\partial^{\mu}\phi\partial_{\mu}\phi$ and $\phi$ is the scalar field.
A. Naruko, D. Langlois, D. Seery, D.H. Lyth, F. Arroja, F. Vernizzi, G.I. Rigopoulos, J.M. Maldacena, K.A. Malik, K.A. Malik, N. Arkani-Hamed, N. Arkani-Hamed, N. Arkani-Hamed, Planck collaboration, R.K. Jain, S. Mukohyama, S. Yokoyama, Shinji Mukohyama, T. Battefeld, T. Kobayashi, WMAP collaboration, WMAP collaboration, WMAP collaboration, X. Chen, Yu-ichi Takamizu   +24 more
core   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

On optical forces in spherical whispering gallery mode resonators

, 2011
In this paper we discuss the force exerted by the field of an optical cavity on a polarizable dipole. We show that the modification of the cavity modes due to interaction with the dipole significantly alters the properties of the force.
Anetsberger, Arcizet, Arnold, Ashkin, Ashkin, Barker, Chang, Chen, Deych, Groeblacher, Hu, J. T. Rubin, Jayich, Kippenberg, L. Deych, Li, Nieto-Vesperinas, Romero-Isart, Romero-Isart, Rubin, Rubin, Schliesser, Schliesser, Schliesser, Schulze, Wilson, Wong, Yin   +27 more
core   +1 more source

From shear stress to wall pressure spectra: a semi-analytical approach to account for mean pressure gradients in turbulent boundary layers [PDF]

, 2022
Simon L. Prigent, Christophe Bailly
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Classification models combined with optimized features for mental stress prediction [PDF]

International Journal of Data and Network Science
Mental stress is a growing global health concern, closely linked to psychological, behavioral, and physiological disorders. Accurate and early prediction of mental stress is crucial for timely interventions and improved health outcomes.
Tran Anh Tuan, Dao Thi Thanh Loan, Bundit Buddhahai   +2 more
doaj   +1 more source