Results 91 to 100 of about 227,622 (300)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Note on the Inverse Reconstruction of Residual Fields in Surface Peened Plates

Latin American Journal of Solids and Structures
A modified stress function approach is developed here to reconstruct induced stress, residual stress and eigenstrain fields from limited experimental measurements.
S. Ali Faghidian
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Stress strain analysis of notched specimen based on material property gradient

, 2012
The stress strain at notch root of round specimen with material property gradient were analysed with elasto-plastic finite element analysis, based on the hardness value obtained from spot welds heat affect zone.
Ruijie Wang, Li, Jianyun, Cheng, Heming, Heming Cheng, Jianyun Li, Wang, Ruijie   +5 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

A study on the stress gradient reconstruction in finite elements problems with application of radial basis function networks [PDF]

, 2019
The recovery of the stress gradient in finite elements problems is a widely discussed topic with many applications in the design process. The stress gradient is related to the second derivative (Hessian) of the nodal displacements and numerical ...
Ballo F., Gobbi M., Previati G.
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Analysis of Fatigue Performance of Metallic Components with Gradient Microstructures

Crystals
Studying the fatigue performance of metallic components and optimizing their design from the perspectives of structure, microstructure, and service conditions has long been a critical research focus.
Pandi Zhao, Liheng Tuo, Hongrui Zhang, Zhiyan Sun, Shuai Ren, Gaihuan Yuan, Zebang Zheng   +6 more
doaj   +1 more source

An energy residual-based approach to gradient effects within the mechanics of generalized continua

Journal of the Mechanical Behavior of Materials, 2012
Generalized continua exhibiting gradient effects are addressed through a method grounded on the energy residual (ER)-based gradient theory by the first author and coworkers.
Polizzotto Castrenze, Pisano Aurora A.
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source