Results 111 to 120 of about 760,552 (308)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Analysis of Fatigue Performance of Metallic Components with Gradient Microstructures
CrystalsStudying the fatigue performance of metallic components and optimizing their design from the perspectives of structure, microstructure, and service conditions has long been a critical research focus.
Pandi Zhao +6 more
doaj +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
DETERMINATION OF THE LIMITING STRESS STATE IN THE TIMBER WITH THE GRADIENT HUMIDITY FIELDS [PDF]
Pro Ligno, 2015 An important task of hydrothermal technology of wood processing is the task of determining the stress tensor components distribution and their permissible values in the dry timber.
Bogdan POBEREYKO +2 more
doaj
RESIDUAL STRESS DISTRIBUTION FOR A SINGLE PASS WELD IN PIPE
Journal of Engineering, 2010 Heat input due to the welding of mild steel pipe causes a temperature gradient in the parent metal. After welding and temperature cooling down, residual stresses appear around welding zone which reduces the weld strength.
Adnan N. Jameel +2 more
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz +25 more
wiley +1 more source
npj Flexible ElectronicsThe biomimetic materials that replicate the mechanical gradient transitions from muscle to tendon to bone remain a significant challenge in tissue engineering, particularly through simple and environmentally friendly approaches.
He Zhu +8 more
doaj +1 more source
Stochastic optimization methods for the simultaneous control of parameter-dependent systems
, 2020 We address the application of stochastic optimization methods for the simultaneous control of parameter-dependent systems. In particular, we focus on the classical Stochastic Gradient Descent (SGD) approach of Robbins and Monro, and on the recently ...
Biccari, Umberto +2 more
core
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source