Results 111 to 120 of about 323,431 (308)

Weight gradience and stress in Portuguese [PDF]

, 2017
This paper examines the role of weight in stress assignment in the Portuguese lexicon, and proposes a probabilistic approach to stress. I show that weight effects are gradient, and weaken monotonically as we move away from the right edge of the word ...
Garcia, Guilherme Duarte, Garcia, Guilherme D., Guilherme D. Garcia   +2 more
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Preparation and characterization of SEBS-g-MAH-filled flexible polyurethane foam composites with gradient-changing structure

Materials & Design, 2019
This study constructs a flexible gradient foaming structure by changes the maleic anhydride-grafted styrene-ethylene/butylene-styrene (SEBS-g-MAH) content on the basis of a two-step foaming technique.
Ting-Ting Li, Wenna Dai, Shih-Yu Huang, Hongyang Wang, Qi Lin, Ching-Wen Lou, Jia-Horng Lin   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

An integrated multidisciplinary approach to study the effects of copper and osmotic stress in fish [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversitySince many estuarine zones are impacted by copper contamination, there is an on-going effort to develop Biotic Ligand Models (BLMs) predicting copper ...
De Polo, Anna
core  

Anti-plane Circular Nano-inclusion Problem with Electric Field Gradient and Strain Gradient Effects [PDF]

, 2014
As well known, gradient theories can describe size effects that are important in nano-scale problems. In this paper, we analyze the Eshelby-type anti-plane inclusion problem embedded in infinite dielectric body by considering both strain gradient and ...
Shengping Shen, Shasha Yang
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Numerical investigation of a coupled moving boundary model of radial flow in low-permeable stress-sensitive reservoir with threshold pressure gradient [PDF]

, 2016
The threshold pressure gradient and formation stress-sensitive effect as the two prominent physical phenomena in the development of a low-permeable reservoir are both considered here for building a new coupled moving boundary model of radial flow in ...
Wan YZ(万义钊), Liu WC(刘文超), Liu YW(刘曰武), Liu, YW (reprint author), Chinese Acad Sci, Inst Mech, Beijing 100190, Peoples R China., Han GF(韩国锋), Niu CC(牛丛丛)   +5 more
core   +1 more source

Multi grade polishing pad for sapphire chemical mechanical polishing

Journal of Materials Research and Technology
The synergy between polishing pad and abrasive is the key to material removal in chemical mechanical polishing (CMP). In order to achieve uniform material removal, a new multi gradient polishing pad for sapphire CMP was developed.
Zhaohui Deng, Rongjin Zhuo, Zhongyang Li, Wei Cao, Shangci Huang, Jimin Ge   +5 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source