Results 101 to 110 of about 323,431 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Severity parameter and global importance factor of non-newtonian models in 3D reconstructed human left coronary artery [PDF]

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Soulis, JV, Giannoglou, GD, Chatzizisis, YS, Seralidou, KV, 3rd Micro and Nano Flows Conference (MNF2011)   +4 more
core  

A control volume-based finite element method for plane micropolar elasticity [PDF]

, 2008
This paper describes the development of a numerical procedure for predicting deformations and stresses in a loaded two-dimensional membrane exhibiting micropolar or Cosserat constitutive behaviour. The procedure employs a conventional finite element (FE)
Wheel, M.A.
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A numerical study of laterally strained wall-bounded turbulence [PDF]

, 2009
Direct numerical simulation (DNS) is used to study the effects of mean lateral divergence and convergence on wall-bounded turbulence, by applying uniform irrotational temporal deformations to a plane-channel domain.
Coleman, G.N., Spalart, P.R., Kim, J., Fedorov, D.   +3 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A Method of X-Ray Stress Measurement for Composite Materials Considering Macro- and Microstresses with Steep Stress Gradient [PDF]

, 1994
This paper describes a study on a method of X-ray stress measurement for the nondestructive determination of the gradient of macro- and micro-residual stress components in the surface layer of composite materials.
Sasaki, Toshihiko, 広瀬, 幸雄, Hirose, Yukio, 40251912, 佐々木, 敏彦, 2675, 20019425, 92462   +7 more
core   +2 more sources

Compound extreme heat and drought stress alter the spatial gradients of protein and starch in wheat grains

Agricultural Water Management
The spatial gradients of protein and starch in wheat grains affected the grain milling characteristics and flour utilization. The increase in compound heat stress and drought stress (HDS) due to global climate change threatens wheat grain yield and ...
Jiangyi Shi, Zhifeng Ding, Xin Ge, Xiaolei Qiu, Junhao Xu, Liujun Xiao, Leilei Liu, Liang Tang, Weixing Cao, Yan Zhu, Bing Liu   +10 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Crack Tip Field and J-Integral with Strain Gradient Effect [PDF]

, 2004
The mode I plane strain crack tip field with strain gradient effects is presented in this paper based on a simplified strain gradient theory within the framework proposed by Acharya and Bassani.
夏嵩, 王自强, 陈少华, Xia, S (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100080, Peoples R China.   +3 more
core