Results 81 to 90 of about 323,431 (308)
International Journal of Mining Science and TechnologyHydraulic fracture growth is significantly influenced by the minimum horizontal principal stress gradient and the fracturing fluid pressure gradient. However, these gradients are often neglected in scaled physical modeling experiments due to difficulties
Junchi Liu +10 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Size-dependent Effects on the Vibration Behavior of a Ti-moshenko Microbeam subjected to Pre-stress Loading based on DQM [PDF]
Mechanics of Advanced Composite Structures, 2016 In this paper, size-dependent effects on the vibration behavior of Timoshenko microbeams under pre-stress loading embedded in an elastic foundation, using modified strain gradient theory (MSGT) and surface stress effects, were studied.
M. Mohammadimehr +3 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Size-dependent stress intensity factors in a gradient elastic double cantilever beam with surface effects [PDF]
, 2018 In this article, the size-dependent stress intensity factors in an elastic double cantilever beam (DCB) are obtained using strain gradient theory. The surface effects are included, while the DCB is assumed to undergo large deformation.
Wang, Baolin (R17839) +2 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Micromechanical analysis of kinematic hardening in natural clay [PDF]
, 2009 This paper presents a micromechanical analysis of the macroscopic behaviour of natural clay. A microstructural stress-strain model for clayey material has been developed which considers clay as a collection of clusters.
Academy of Finland (Grant 210744) (Funder) +17 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
工程科学与技术, 2016 :In order to study the influence of residual stress on rolling contact, a simplified 2-D finite element model of cylindrical roller bearing was established.
chenpengfei, wangjiaxu
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source