Results 61 to 70 of about 323,431 (308)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Mode I and Mode II Crack Tip Asymptotic Fields with Strain Gradient Effects [PDF]

open access: yes, 2001
The strain gradient effect becomes significant when the size of fracture process zone around a crack tip is comparable to the intrinsic material length l, typically of the order of microns.
Chen, SH (reprint author), Chinese Acad Sci, Inst Mech, LNM, Beijing 100080, Peoples R China.   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Micrometre-scale plasticity size effects in metals and ceramics: theory and experiment. [PDF]

open access: yes, 2009
PhDThis thesis comprises studies of size effects in the plasticity of metals and ceramics at length scales of the order of micrometres and includes both experimental work and theoretical development. Experimental results are presented for foil flexure
Zhu, Tingting
core  

On stress-gradient materials: formulation and homogenization [PDF]

open access: yes, 2018
International audienceThe stress-gradient model was introduced by Forest and Sab(Mech. Res. Comm. 40, pp. 16–25, 2012) as an alternative to the more popularstrain-gradient models.
Brisard, Sébastien   +3 more
core   +3 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

A minimal gradient-enhancement of the classical continuum theory of crystal plasticity. Part I: The hardening law

open access: yesArchives of Mechanics, 2016
A simple gradient-enhancement of the classical continuum theory of plasticity of single crystals deformed by multislip is proposed for incorporating size effects in a manner consistent with phenomenological laws established in materials science.
H. Petryk, S. Stupkiewicz
doaj   +1 more source

Analysis of dynamics variation against thixotropic parameter’s preferential range [PDF]

open access: yesTheoretical and Applied Mechanics, 2018
Variation in the dynamics of a steady-state blood flow through a stenosed tapered artery has been investigated corresponding to changes in thixotropic parameter λ over the range [0,1].
Shahid Nazish
doaj   +1 more source

Non-Newtonian and flow pulsatility effects in simulation models of a stented intracranial aneurysm [PDF]

open access: yes, 2011
Permission to redistribute provided by publishers.Three models of different stent designs implanted in a cerebral aneurysm, originating from the Virtual Intracranial Stenting Challenge'07, are meshed and the flow characteristics simulated using ...
BAROZZI, Giovanni Sebastiano   +11 more
core   +1 more source

Home - About - Disclaimer - Privacy