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2022
Stress granules (SGs) are cytosolic ribonucleoprotein granules that form via a liquid-liquid phase separation in response to environmental stresses such as heat, oxidative, and osmotic changes. Due to the condensation of low complexity, hydrophobic regions in core SG components in these highly dynamic granules, defects in SG maintenance and formation ...
Elizabeth J, Alexander, Jiou, Wang
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Stress granules (SGs) are cytosolic ribonucleoprotein granules that form via a liquid-liquid phase separation in response to environmental stresses such as heat, oxidative, and osmotic changes. Due to the condensation of low complexity, hydrophobic regions in core SG components in these highly dynamic granules, defects in SG maintenance and formation ...
Elizabeth J, Alexander, Jiou, Wang
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Stress granules and hormetic adaptation of cancer
Trends in Cancer, 2023Cell stress is inherent to cancer and a key driver of tumorigenesis. Recent studies have proposed that cell stress promotes tumorigenesis through non-membranous organelles known as stress granules (SGs). While the biology of SGs is an emerging field, all studies to date point to the enhanced ability of cancer cells to form SGs compared with normal ...
Alexandra Redding, Elda Grabocka
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Metabolites control stress granule disassembly
Nature Cell Biology, 2021Cells respond to stimuli by reorganizing their contents into subcellular structures. New research demonstrates that yeast pyruvate kinase Cdc19 interacts with fructose-1,6-bisphosphate to coordinate disassembly of stress granules. These findings reveal how proteins can directly sense the cellular energy state to facilitate adaptive reorganization.
Christopher M. Jakobson +1 more
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Surviving Stress by Going to Stress Granules
Science's STKE, 2005Cells and even entire animals exposed to nonlethal stress, such as exposure to high temperature, tolerate subsequent stresses that would be lethal to a cell or animal not thus preconditioned. One mechanism for this effect of heat-stress preconditioning is inhibition of the inflammatory pathway mediated by nuclear factor κB (NF-κB) and the ...
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Mammalian Stress Granules and Processing Bodies
2007The packaging of cytoplasmic mRNA into discrete RNA granules regulates gene expression by delaying the translation of specific transcripts. Specialized RNA granules found in germ cells direct the timing of maternal mRNA translation to promote germ cell development in the early embryo and establish the germ line for the next generation.
Nancy, Kedersha, Paul, Anderson
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