Results 231 to 240 of about 4,058,220 (323)

TARDBP (TDP‐43) Knock‐in Zebrafish Display a Late‐Onset Motor Phenotype and Loss of Large Spinal Cord Motor Neurons

Annals of Neurology, EarlyView.
Objective Mutations in TARDBP (encoding TDP‐43) are associated with the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and include familial missense mutations where there are a lack of models and mechanisms examining how they are pathogenic.
Ziyaan A. Harji, Christian J. Rampal, Esteban C. Rodríguez, Virginie Petel Légaré, Alexandra Lissouba, Sabrina Semmler, Meijiang Liao, Jay P. Ross, Guy A. Rouleau, Christine Vande Velde, Gary A.B. Armstrong   +10 more
wiley   +1 more source

Stress granules promote quiescence by enhancing p21 levels and reducing phospho-Rb. [PDF]

RNA
Khong A, Ripin N, de Vasconcelos LM, Passanisi V, Spencer S, Parker R.   +5 more
europepmc   +1 more source

The Hsp90 Inhibitor Geldanamycin Abrogates Colocalization of eIF4E and eIF4E-Transporter into Stress Granules and Association of eIF4E with eIF4G [PDF]

, 2009
Yukari Suzuki, Michiko Minami, Miho Suzuki, Keiko Abe, Shuhei Zenno, Masafumi Tsujimoto, Ken Matsumoto, Yasufumi Minami   +7 more
openalex   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, EarlyView.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

Assembly and disassembly of stress granules in kidney diseases. [PDF]

iScience
Zhu J, Su H.
europepmc   +1 more source

Author response for "Detecting and quantifying stress granules in tissues of multicellular organisms with the <i>Obj.MPP</i> analysis tool"

, 2019
Fabienne De Graeve, Éric Debreuve, Somia Rahmoun, Szilvia Ecsedi, Alia Bahri, Arnaud Hubstenberger, Xavier Descombes, Florence Besse   +7 more
openalex   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Host Translational Control by Stress Granules Promotes <i>Mycobacterium tuberculosis</i> Pathogenesis. [PDF]

MedComm (2020)
Kim J, Son SH, Choi JA, Lee J, Jo S, Cho SN, Nguyen DT, Son D, Kim KK, Song CH.   +9 more
europepmc   +1 more source

Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells [PDF]

, 2019
Katrin Riemschoss, Verena Arndt, Benedetta Bolognesi, Philipp von Eisenhart-Rothe, Shu Liu, Oleksandra Buravlova, Yvonne Duernberger, Lydia Paulsen, Annika Hornberger, André Hossinger, Nieves Lorenzo-Gotor, Sebastian Hogl, Stephan A. Müller, Gian Gaetano Tartaglia, Stefan F. Lichtenthaler, Ina Vorberg   +15 more
openalex   +1 more source

In long-lasting cellular stress phases of melanoma cells, stress granules are dissolved by HSP70. [PDF]

Cell Mol Life Sci
Staebler S, Pieger K, Perl J, Stieglitz D, Thongmao A, Schneider N, Bosserhoff AK, Kuphal S.   +7 more
europepmc   +1 more source