Results 51 to 60 of about 2,717,503 (245)

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Chronic Stress Exacerbates Hyperglycemia-Induced Depressive-Like Behavior in Male Mice. [PDF]

, 2023
Among chronically ill populations, affective disorders remain underdiagnosed and undertreated. A high degree of comorbidity exists between diabetes and affective disorders, particularly depression and anxiety.
McCready, Riley.
core   +1 more source

Frequency of stress hyperglycemia in admitted patients (2 days to 14 years of age) in Qaem Hospital, Hamadan

مجله دانشگاه علوم پزشکی گرگان, 2003
Background and Objective: Stress hyperglycemia (Transient rise of blood sugar during acute physiologic stress) has been reported in adults in conditions such as trauma, burns, stroke, myocardial infraction and patients admitted for any cause in intensive
Z.Razavi (M.D), I.Ramezani (M.D)
doaj  

Stress hyperglycemia: clinical profile and outcome in critically ill children

, 2017
Background: Stress hyperglycemia (SH) occurs commonly during critical illness in children with previously normal glucose homeostasis. Objective of present study was to study the clinical presentation, underlying illness and the outcome of stress ...
Diana Grace R., Poovazhagi V.
core   +1 more source

A randomized trial of hyperglycemic control in pediatric intensive care. [PDF]

, 2014
BACKGROUND: Whether an insulin infusion should be used for tight control of hyperglycemia in critically ill children remains unclear. METHODS: We randomly assigned children (≤16 years of age) who were admitted to the pediatric intensive care unit (ICU ...
Allen, Elizabeth, Grieve, Richard, Morris, Kevin, Sadique, Zia, Parslow, Roger, Elbourne, Diana, CHiP Investigators, Macrae, Duncan, Pappachan, John, Tasker, Robert C   +9 more
core   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Stress Hyperglycemia and Complications Following Traumatic Injuries in Individuals With/Without Diabetes: The Case of Orthopedic Surgery

Diabetes, Metabolic Syndrome and Obesity, 2020
Raffaella Di Luzio,1 Rachele Dusi,2 Arianna Mazzotti,2,3 Maria Letizia Petroni,2 Giulio Marchesini,2 Giampaolo Bianchi2 1Unit of Internal Medicine – AUSL Bologna, Bologna, Italy; 2Department of Medical and Surgical Sciences (DIMEC), “Alma ...
Di Luzio R, Dusi R, Mazzotti A, Petroni ML, Marchesini G, Bianchi G   +5 more
doaj  

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

The predictive value of stress-induced hyperglycemia parameters for delayed healing after tibial fracture post-surgery

Journal of Orthopaedic Surgery and Research
Purpose The objective of this retrospective cohort study was to investigate the predictive value of stress-induced hyperglycemia parameters for delayed healing after tibial fracture post-surgery.
Xiang Ji, Dunxu Zhao, Zetuan Xin, Hai Feng, Zhiyong Huang   +4 more
doaj   +1 more source