Results 191 to 200 of about 66,068 (243)

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Unveiling the relationship between stress-hyperglycemia ratio and cardiometabolic multimorbidity risk using interpretable machine learning. [PDF]

Eur J Med Res
Wei S, Yu S, Qian C, Lan Y, Xufeng H.
europepmc   +1 more source

Immune checkpoint inhibitor‐induced arrhythmias: Mechanistic insights from clinical and preclinical studies

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitors (ICIs) have transformed cancer therapy, but their efficacy continues to be limited by immune‐related adverse events. Among these, ICI‐induced cardiac arrhythmias are increasingly recognised as a major adverse reaction, encompassing a broad spectrum of clinical phenotypes, including conduction blocks, atrial fibrillation and
Anand R. Ramalingam, Zoltán Márton Köhler, Péter Ferdinandy, Zoltán V. Varga   +3 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Stress hyperglycemia ratio in coronary artery disease: a systematic review and meta-analysis of severity and prognosis. [PDF]

Cardiovasc Diabetol
Wang C, Liang S, Zhang J, Lang Q, Huang X, Liu L, Liu J, Yi Y, Tian L, Yu X.   +9 more
europepmc   +1 more source

Kininase I drives angiotensin II‐induced hypertension through activation of the bradykinin B1 receptor

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White, Drew Theobald, Alexandra Johnston, David A. Tulis, Johanna Hannan, Srinivas Sriramula   +5 more
wiley   +1 more source

Stress hyperglycemia ratio predicts adverse outcomes in emergency department patients with upper gastrointestinal bleeding. [PDF]

PLoS One
Ou HC, An YC, Shih CC, Lai CY, Chiang HH, Chien WC, Liao WI, Tsai SH.   +7 more
europepmc   +1 more source

Association of Life's Essential 8 Score With Incident Pancreatic Cancer: A Prospective Cohort Study in Shanghai, China

Cancer Science, EarlyView.
In this prospective cohort study of 60,556 cancer‐free adults with a median follow‐up of 7.44 years, a higher Life's Essential 8 (LE8) score, reflecting better cardiovascular health, was associated with a lower risk of pancreatic cancer (PC). Each 1‐SD increase in LE8 score was associated with an 18% lower PC risk.
Liping Yi, Xing Liu, Maryam Zaid, Kexin Zhang, Biying Wang, Yingqi Deng, Minhua Tang, Yonggen Jiang, Genming Zhao   +8 more
wiley   +1 more source

Association between stress hyperglycemia ratio and ICU delirium among critically ill adults in MIMIC-IV. [PDF]

Sci Rep
Wang C, Lv L, Ma R, Dong H.
europepmc   +1 more source

Stratified Randomized Controlled Trial of ∅3.3 mm Versus ∅4.1 mm Hydrophilic Titanium‐Zirconium Implants Supporting Posterior Mandibular Fixed Prostheses in Hyperglycaemic Subjects

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objective To compare ⌀3.3 mm and ⌀4.1 mm hydrophilic titanium‐zirconium implants supporting fixed dental prostheses (FDPs) in mandibular distal‐extension situations among participants with varying degrees of hyperglycaemia. Materials and Methods Participants were stratified according to HbA1c (5.8%–< 7.0% vs.
Supriya Ebenezer, Sreelakshmi Viswanath, Chitradevi Ramanathan, Alampalli V. Ramesh, Vinay V. Kumar   +4 more
wiley   +1 more source