Results 201 to 210 of about 5,412,654 (273)

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

open access: yesVIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf   +5 more
wiley   +1 more source

Progress in bone tissue engineering biomaterials: Development, challenges, and prospects

open access: yesVIEW, EarlyView.
Scheme 1 Application of biomaterials in immunomodulation during bone tissue engineering. Abstract Bone defect repair remains a major clinical challenge in orthopedics. Over 2 million cases caused by trauma, tumors, and other factors occur annually, with large‐scale defects posing a particular bottleneck due to limited self‐healing capacity.
Yuanbin Zhang   +7 more
wiley   +1 more source

Four‐dimensional immuno‐mechanobiomaterials: Dynamic material cues that program host response to prevent fibrosis and enable regeneration

open access: yesVIEW, EarlyView.
Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan   +4 more
wiley   +1 more source

Gut microbiota dysbiosis in the inflammatory pathogenesis of diabetic retinopathy

open access: yesVIEW, EarlyView.
This graphical abstract illustrates how gut dysbiosis drives diabetic retinopathy through the gut‐retina axis, a process unfolding in three interconnected stages. First, in the gut, a decrease in beneficial bacteria and an increase in pro‐inflammatory taxa compromise the intestinal barrier, causing a “leaky gut” that allows LPS to translocate into the ...
Junyan Hu, Jingxiang Zhong
wiley   +1 more source

Correction to: Prognostic significance of the stress hyperglycemia ratio in critically ill patients

open access: yesCardiovascular Diabetology
Le Li   +7 more
openaire   +2 more sources

Local Low‐Frequency Vibration Enhances Wound‐Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model

open access: yesThe Journal of Dermatology, EarlyView.
ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba   +6 more
wiley   +1 more source

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