Results 131 to 140 of about 4,711,500 (287)

Local approaches for the fracture assessment of notched components: the research work developed by Professor Paolo Lazzarin

Fracture and Structural Integrity, 2015
Brittle failure of components weakened by cracks or sharp and blunt V-notches is a topic of active and continuous research. It is attractive for all researchers who face the problem of fracture of materials under different loading conditions and deals ...
F. Berto
doaj  

Stress Intensity Factor Assessment for the Reinforcement of Cracked Steel Plates Using Prestressed or Non-Prestressed Adhesively Bonded CFRP. [PDF]

Materials (Basel), 2021
Lepretre E, Chataigner S, Dieng L, Gaillet L.   +3 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A new formulation for estimating maximum stress intensity factor at the mid plane of a SENB specimen: Study based on 3D FEA

Fracture and Structural Integrity, 2014
In this investigation, three-dimensional elastic finite element analyses have been conducted to compute the stress intensity factor (KI) in a SENB specimen with varied thickness (B) and crack-length to width ratio (a/W).
S. K. Kudari, K. G. Kodancha
doaj  

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Effect of Specimen Thickness and Stress Intensity Factor Range on Plasticity-Induced Fatigue Crack Closure in A7075-T6 Alloy. [PDF]

Materials (Basel), 2021
Masuda K, Ishihara S, Oguma N.
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

STRESS INTENSITY FACTOR FOR CRACKED FLAT-ELLIPTIC CROSS-SECTION PIPE

Jixie qiangdu, 2017
As an important parameter to assess the crack pipe fracture toughness,stress intensity factor determined is particularly important. In order to solve practical engineering problems,most of them are three-dimensional crack problems,crack mouth widening ...
LI Chong, XIE YuJun
doaj  

Direct Computation of 3-D Stress Intensity Factors of Straight and Curved Planar Cracks with the P-Version Finite Element Method and Contour Integral Method. [PDF]

Materials (Basel), 2021
Zhang J, Xu R, He Y, Yang W.
europepmc   +1 more source