Results 31 to 40 of about 778,674 (264)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Modified stress intensity factor as a crack growth parameter applicable under large scale yielding conditions

open access: yesMechanical Engineering Journal, 2014
High-temperature water stress corrosion cracking has high tensile stress sensitivity, and its growth rate has been evaluated using the stress intensity factor, which is a linear fracture mechanics parameter.
Tetsuo YASUOKA   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Researches Concerning the Deformation Behaviour of Low Carbon Steel

open access: yesThe Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2008
The paper shows the results of the researches meant to establish the equation of deformation behavior of low carbon steel. The behavior law is established by the experimental way, using the torsion test method. The composed constitutive law had very good
Nicolae CANANAU   +3 more
doaj  

Revisiting classical concepts of Linear Elastic Fracture Mechanics - Part III: The stress field in a double-edge notched finite strip by means of the �stress-neutralization� technique

open access: yesFracture and Structural Integrity
This is the third part of a short series of paper, revisiting some classical concepts of Linear Elastic Fracture Mechanics. Based on the solution for the single edge notched strip, discussed in Part-II, the present study deals with the stress field ...
Christos F. Markides   +1 more
doaj   +1 more source

Distinguishing the Effects of Stress Intensity and Stress Duration in Plant Responses to Salinity

open access: yesPlants, 2023
Species-specific variation in response to stress is a key driver of ecological patterns. As climate change alters stress regimes, coastal plants are experiencing intensifying salinity stress due to sea-level rise and more intense storms.
Caitlin DiCara, Keryn Gedan
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

On Suppression of Vibrations of Three-Layered Beam Containing Magnetorheological Composite

open access: yesМеханика машин, механизмов и материалов, 2010
Obtained in parametric form, exact analytical expressions for the components of stresses, deformations and displacements arising in physically nonlinear viscoelastic on according to Vladimir Moskvitin mechanically incompressible plate of constant ...
L.H. Talibli , G.N. Agayev
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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