Results 41 to 50 of about 778,674 (264)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Relationship Between Stress, its Management and Public Well-being in Lithuania: Effect of Sociodemographic and Clinical Factors

Social Welfare: Interdisciplinary Approach
The aim of the study was to assess the individual stress intensity and its management in Lithuania in the context of public well-being, concentrating on the effects of socio-demographic and clinical factors on stress intensity.
Lolita Rapolienė, Diana Šaparnienė, Arvydas Martinkėnas, Inga Dailidienė, Aelita Bredelytė, Gintarė Grigaliūnaitė, Dovydas Rapolis   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Stress intensity solutions for cracked orthotropic plates

EPJ Web of Conferences, 2010
In this paper, fracture mechanics in orthotropic plates, stress and displacement distributions around the crack tip in an anisotropic material are considered.
Rahmani O., Boutchicha D., Kebdani S., Sahli A.   +3 more
doaj   +1 more source

Relation between intensity of singular stress at interface edge and stress intensity factor of small edge interface crack in butt joint

Nihon Kikai Gakkai ronbunshu, 2016
This paper deals with the effect of adhesion layer and material combination on the stress intensity factor for small edge interface crack in butt joint plate under uniaxial tension.
Kazuhiro ODA, Yosuke TAKAHATA, Nao-Aki NODA, Noriko TSUTSUMI   +3 more
doaj   +1 more source

Experimental Study on the Caustics of Moving Cracks and Elliptical Curvature under Impact Loading

Advances in Civil Engineering, 2021
A dynamic caustics test system was used, and different moving cracks were analysed to study the interaction between the crack growth rate, stress intensity factor, and curvature of the elliptical end of a moving crack under impact loading.
Haohao Luo, Renshu Yang, Yanbing Wang, Guoliang Yang, Chengxiao Li, Chen An, Yuantong Zhang   +6 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source