Results 61 to 70 of about 4,711,500 (287)

Experimental Study on the Caustics of Moving Cracks and Elliptical Curvature under Impact Loading

Advances in Civil Engineering, 2021
A dynamic caustics test system was used, and different moving cracks were analysed to study the interaction between the crack growth rate, stress intensity factor, and curvature of the elliptical end of a moving crack under impact loading.
Haohao Luo, Renshu Yang, Yanbing Wang, Guoliang Yang, Chengxiao Li, Chen An, Yuantong Zhang   +6 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Experimental Researches on the Constitutive Equation of Concrete Steel With Superior Characteristics

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2007
The plastic deformation behavior is defined by the function of the deformation strength according to the strain, strain rate and temperature as the factor of the deformation process. The behavior law establishes by the experimental way, using the torsion
Nicolae CĂNĂNĂU, Petrică ALEXANDRU, Gheorghe GURĂU, Ionel PETREA   +3 more
doaj  

A modelling technique for calculating stress intensity factors for structures reinforced by bonded straps. Part II: Validation [PDF]

, 2010
In this second part of the two-part paper validation of the 2D FE modelling technique described in the first part is presented for a range of test configurations.
Boscolo, Marco, Zhang, Xiang
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Higher Intensity of Salt Stress Accompanied by Heat Inhibits Stomatal Conductance and Induces ROS Accumulation in Tomato Plants

Antioxidants
Under natural conditions, abiotic stresses that limit plant growth and development tend to occur simultaneously, rather than individually. Due to global warming and climate change, the frequency and intensity of heat and salt stresses are becoming more ...
Yankai Li, Fangling Jiang, Zhenxiang He, Yi Liu, Zheng Chen, Carl-Otto Ottosen, Ron Mittler, Zhen Wu, Rong Zhou   +8 more
doaj   +1 more source

Development of strain gages to analyze the stress intensity factor of a crack tip

Nihon Kikai Gakkai ronbunshu, 2015
There are currently one or two kinds of strain gages to measure the stress intensity factor. It might not be sometimes easy to analyze the stress intensity factor with those gages.
Shigeru KUROSAKI, Syusaku YAMAJI, Ryo KOBARI, Mitsutaka KANEHIRA, Takeshi SHIMURA, Jyo SHIMURA   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source