Results 111 to 120 of about 1,437,569 (357)

Mode I analysis of a cracked circular disk subject to a couple and a force [PDF]

open access: yes
Mode 1 stress intensity coefficients were obtained for an edge-cracked disk (round compact specimen). Results for this plane elastostatic problem, obtained by a boundary collocation analysis are presented for ratios 0.35 less than A/D less than 1, where ...
Gross, B.
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Stress analysis of cracks [PDF]

open access: yes
Elastic stress analyses of cracked bodies represented by stress intensity factor method - fracture ...
Paris, P. C., Sih, G. C.
core   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Characterization of stress-strain state in gas turbine engine compressor disc taking into account damage accumulation

open access: yesFracture and Structural Integrity, 2019
The stress-strain state analysis of the gas turbine engine compressor disk was carried out taking into account damage accumulation under various loading conditions in the temperature range.
Natalia V Boychenko, Ivan Ishtyryakov
doaj  

Three dimensional finite-element analysis of finite-thickness fracture specimens [PDF]

open access: yes
The stress-intensity factors for most of the commonly used fracture specimens (center-crack tension, single and double edge-crack tension, and compact), those that have a through-the-thickness crack, were calculated using a three dimensional finite ...
Newman, J. C., Jr., Raju, I. S.
core   +1 more source

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