Results 91 to 100 of about 8,232,558 (285)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Threshold intensity factors as lower boundaries for crack propagation in ceramics

BioMedical Engineering OnLine, 2004
Background Slow crack growth can be described in a v (crack velocity) versus KI (stress intensity factor) diagram. Slow crack growth in ceramics is attributed to corrosion assisted stress at the crack tip or at any pre-existing defect in the ceramic. The
Walter Per-Ole, Jungwirth Franz, Marx Rudolf   +2 more
doaj   +1 more source

Prediction Model of Stress Intensity Factor of Circumferential Through Crack in Elbow Based on Neural Network. [PDF]

Comput Intell Neurosci, 2022
Li X, Li X, Chen B.
europepmc   +1 more source

Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling [PDF]

, 2014
This investigation examined the impact of Montmorency tart cherry concentrate (MC) on physiological indices of oxidative stress, inflammation and muscle damage across 3 days simulated road cycle racing.
Stevenson, Emma, Phillip Bell, Bell, Phillip, Gareth Davison, Emma Stevenson, Howatson, Glyn, Glyn Howatson, Davison, Gareth, Walshe, Ian, Ian Walshe   +9 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Relation between intensity of singular stress at interface edge and stress intensity factor of small edge interface crack in butt joint

Nihon Kikai Gakkai ronbunshu, 2016
This paper deals with the effect of adhesion layer and material combination on the stress intensity factor for small edge interface crack in butt joint plate under uniaxial tension.
Kazuhiro ODA, Yosuke TAKAHATA, Nao-Aki NODA, Noriko TSUTSUMI   +3 more
doaj   +1 more source

Influence of Stress Intensity Factor on Rail Fatigue Crack Propagation by Finite Element Method. [PDF]

Materials (Basel), 2021
Gao R, Liu M, Wang B, Wang Y, Shao W.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Stress Intensity Factor for Aluminum and Copper Spot Weld Joints

Journal of Applied Science and Engineering
For decades, resistance spot welding (RSW) between aluminum and copper has encountered difficulties; however, it remains essential for modern applications.
Marwah Sabah Fakhri, Ahmed Al-Mukhtar, Ibtihal A. Mahmood   +2 more
doaj   +1 more source

Notch Effects on the Stress Intensity Factor and on the Fatigue Crack Path for Eccentric Circular Internal Cracks in Elliptically Notched Round Bars under Tensile Loading. [PDF]

Materials (Basel), 2022
Toribio J, González B, Matos JC, González I.   +3 more
europepmc   +1 more source