CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Approximate determination of stress intensity factor for multiple surface cracks [PDF]
FME Transactions, 2018 In this paper a versatile and easy to use approximate procedure was used for the estimation of mode I stress intensity factors in case of multiple surface cracks in a three dimensional elastic body, subjected to remote uniaxial tensile loading.
Kastratović Gordana +3 more
doaj
A Review on Reductions in the Stress-Intensity Factor of Cracked Plates Using Bonded Composite Patches. [PDF]
Materials (Basel), 2022 Aabid A, Hrairi M, Ali JSM, Sebaey TA.
europepmc +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Threshold intensity factors as lower boundaries for crack propagation in ceramics
BioMedical Engineering OnLine, 2004 Background Slow crack growth can be described in a v (crack velocity) versus KI (stress intensity factor) diagram. Slow crack growth in ceramics is attributed to corrosion assisted stress at the crack tip or at any pre-existing defect in the ceramic. The
Walter Per-Ole +2 more
doaj +1 more source
Prediction Model of Stress Intensity Factor of Circumferential Through Crack in Elbow Based on Neural Network. [PDF]
Comput Intell Neurosci, 2022 Li X, Li X, Chen B.
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Influence of Stress Intensity Factor on Rail Fatigue Crack Propagation by Finite Element Method. [PDF]
Materials (Basel), 2021 Gao R, Liu M, Wang B, Wang Y, Shao W.
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Notch Effects on the Stress Intensity Factor and on the Fatigue Crack Path for Eccentric Circular Internal Cracks in Elliptically Notched Round Bars under Tensile Loading. [PDF]
Materials (Basel), 2022 Toribio J +3 more
europepmc +1 more source