Results 71 to 80 of about 1,447,308 (304)
Stress analysis of cracks [PDF]
Elastic stress analyses of cracked bodies represented by stress intensity factor method - fracture ...
Paris, P. C., Sih, G. C.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Strain intensity factor approach for predicting the strength of continuously reinforced metal matrix composites [PDF]
A method was previously developed to predict the fracture toughness (stress intensity factor at failure) of composites in terms of the elastic constants and the tensile failing strain of the fibers.
Poe, C. C., Jr.
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Stress-intensity factor calculations using the boundary force method [PDF]
The Boundary Force Method (BFM) was formulated for the three fundamental problems of elasticity: the stress boundary value problem, the displacement boundary value problem, and the mixed boundary value problem.
Newman, J. C., Jr. +2 more
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Studying the Effect of Pulse Shape on Dynamic Stress Intensity Factor at the Finite Crack Tip using Displacement Fields [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2020 In analytical studies, step (Heaviside) function is used to simulate an impact load. However, in real behaviour of materials, loading and unloading take a short time.
Hossein Rahmani +1 more
doaj
Fatigue crack growth in unidirectional metal matrix composite [PDF]
The weight function method was used to determine the effective stress intensity factor and the crack opening profile for a fatigue tested composite which exhibited fiber bridging. The bridging mechanism was modeled using two approaches; the crack closure
Ghosn, Louis J. +2 more
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Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Effect of debond growth on stress-intensity factors in a cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]
Stress-intensity factors are determined for a cracked infinite sheet adhesively bonded to a stringer, and debonding of the adhesive layer is predicted. The stringer is modeled as a semi-infinite sheet. Adhesive nonlinearity is also included.
Bigelow, C. A.
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