Results 51 to 60 of about 1,447,308 (304)
ISOGEOMETRIC ANALYSIS OF STRESS INTENSITY FACTOR IN V-NOTCHED PLANE
Jixie qiangdu, 2022 In this paper, an isogeometric analysis method is proposed to obtain the notch tip stress intensity factor for the plane fracture problem with V-notch.
XU Wang, ZHONG DongWang, CAI LuJun
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Stress and Displacement Intensity Factors of Cracks in Anisotropic Media
International Journal of Applied Mechanics and Engineering, 2020 A relation connecting stress intensity factors (SIF) with displacement intensity factors (DIF) at the crack front is derived by solving a pseudodifferential equation connecting stress and displacement discontinuity fields for a plane crack in an elastic ...
S. Kuznetsov, A. Karakozova
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
STRESS INTENSITY FACTOR FOR CRACKED FLAT-ELLIPTIC CROSS-SECTION PIPE
Jixie qiangdu, 2017 As an important parameter to assess the crack pipe fracture toughness,stress intensity factor determined is particularly important. In order to solve practical engineering problems,most of them are three-dimensional crack problems,crack mouth widening ...
LI Chong, XIE YuJun
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Nihon Kikai Gakkai ronbunshu, 2016 Crack opening displacement around a mode I surface crack tip was measured by digital image correlation method to determine the stress intensity factor and the effective stress intensity factor range.
Yuichi ONO +2 more
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FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
STUDY ON STRESS INTENSITY FACTOR OF THREE DIMENSION MODEL OF TYPEⅠCRACK IN TYPICAL LUG JOINT
Jixie qiangdu, 2018 On the basis of two-dimension finite element analysis,the two-dimension stress intensity factor correction coefficients of typical lug joint were obtained; Three dimension elastic plastic contact finite element model of the typical lug joint was ...
WANG XinBo +4 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source