Results 41 to 50 of about 534,838 (263)

A new formulation for estimating maximum stress intensity factor at the mid plane of a SENB specimen: Study based on 3D FEA

open access: yesFracture and Structural Integrity, 2014
In this investigation, three-dimensional elastic finite element analyses have been conducted to compute the stress intensity factor (KI) in a SENB specimen with varied thickness (B) and crack-length to width ratio (a/W).
S. K. Kudari, K. G. Kodancha
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

STRESS INTENSITY FACTOR FOR CRACKED FLAT-ELLIPTIC CROSS-SECTION PIPE

open access: yesJixie qiangdu, 2017
As an important parameter to assess the crack pipe fracture toughness,stress intensity factor determined is particularly important. In order to solve practical engineering problems,most of them are three-dimensional crack problems,crack mouth widening ...
LI Chong, XIE YuJun
doaj  

Analysis of Stress Intensity Factors for Curved Cracks.

open access: yesTRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1993
In this paper, the hypersingular integral equation method (HIEM) is applied to calculate the stress intensity factors of curved crack problems. The stress fields induced by two kinds of displacement discontinuity are used as fundamental solutions. Then, the problem is formulated as a system of integral equations with the singularity of the form of r-2.
Noda, Nao-Aki   +2 more
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Stress and Displacement Intensity Factors of Cracks in Anisotropic Media

open access: yesInternational Journal of Applied Mechanics and Engineering, 2020
A relation connecting stress intensity factors (SIF) with displacement intensity factors (DIF) at the crack front is derived by solving a pseudodifferential equation connecting stress and displacement discontinuity fields for a plane crack in an elastic ...
S. Kuznetsov, A. Karakozova
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Measurement of the stress intensity factor and the effective stress intensity factor range of a mode I surface crack using the digital image correlation method

open access: yesNihon Kikai Gakkai ronbunshu, 2016
Crack opening displacement around a mode I surface crack tip was measured by digital image correlation method to determine the stress intensity factor and the effective stress intensity factor range.
Yuichi ONO   +2 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Evaluation of stress intensity factor for small edge interface crack under thermal stress

open access: yesNihon Kikai Gakkai ronbunshu, 2015
This paper deals with the analysis of the thermal stress intensity factor for small edge interfacial crack between bonded dissimilar plates subjected to uniform change of temperature by using the crack tip stress method.
Kazuhiro ODA   +3 more
doaj   +1 more source

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