From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Studying the Effect of Pulse Shape on Dynamic Stress Intensity Factor at the Finite Crack Tip using Displacement Fields [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2020 In analytical studies, step (Heaviside) function is used to simulate an impact load. However, in real behaviour of materials, loading and unloading take a short time.
Hossein Rahmani +1 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Study of Effective Stress Intensity Factor through the CJP Model Using Full-Field Experimental Data. [PDF]
Materials (Basel), 2023 Camacho-Reyes A +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Fracture and Structural Integrity, 2019 A stress-strain state analysis of a gas turbine engine compressor disc was conducted with consideration to the accumulation of damages under various loading conditions in the temperature range.
Natalia Boychenko, Ivan Ishtyryakov
doaj +1 more source
Predicting Stress Intensity Factor for Aluminum 6062 T6 Material in L-Shaped Lower Control Arm (LCA) Design Using Extended Finite Element Analysis. [PDF]
Materials (Basel), 2023 El Fakkoussi S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Stress Intensity Factor (SIF) Solutions and Fatigue Crack Paths in Eccentric Circumferentially Cracked Round Bar (CCRB) in Tension. [PDF]
Materials (Basel), 2023 Toribio J, Matos JC, González B.
europepmc +1 more source