Results 161 to 170 of about 1,528,319 (313)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Transverse shear effects on the stress-intensity factor for a circumferentially cracked, specially orthotropic cylindrical shell [PDF]
The problem of a cylindrical shell containing a circumferential through crack is considered by taking into account the effect of transverse shear deformations.
Delale, F., Erdogan, F.
core +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Two bonded half planes with a crack going through the interface [PDF]
The plane problem of two bonded elastic half planes containing a finite crack perpendicular to and going through the interface is considered. The problem is formulated as a system of singular integral equations with generalized Cauchy kernels.
Biricikoglu, V., Erdogan, F.
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Stress-intensity factor equations for cracks in three-dimensional finite bodies [PDF]
Empirical stress intensity factor equations are presented for embedded elliptical cracks, semi-elliptical surface cracks, quarter-elliptical corner cracks, semi-elliptical surface cracks at a hole, and quarter-elliptical corner cracks at a hole in finite
Newman, J. C., Jr., Raju, I. S.
core +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
A clamped rectangular plate containing a crack [PDF]
The general problem of a rectangular plate clamped along two parallel sides and containing a crack parallel to the clamps is considered. The problem is formulated in terms of a system of singular integral equations and the asymptotic behavior of the ...
Erdogan, F., Tang, R.
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Fracture study of windshield glass panes [PDF]
The major stresses which cause crack propagation in windshield glass panes are induced by bending moments which result from the pressure differentials across the panes.
Yeh, H. Y.
core +1 more source