Results 51 to 60 of about 2,487,134 (354)

Fracture mechanics approach to design analysis of notches, steps and internal cut-outs in planar components [PDF]

, 2007
A new approach to the assessment and optimization of geometric stress-concentrating features is proposed on the basis of the correspondence between sharp crack or corner stressfield intensity factors and conventional elastic stress concentration factors (
J Wood, Murakami Y., Neuber H., T. G F Gray, Timoshenko S., Young W. C.   +5 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Cracking Characteristics of Different Crack Forms in Pavement under Moving Load

Engineering Transactions
In road engineering, the crack damage problems are one of the essential research areas that need to be emphasized. However, there have been few researches on the effects caused by different crack forms, e.g., the impacts of the distribution and ...
Guannan YAN
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The centrally cracked Brazilian disc: implications and solutions in case of closing cracks

Journal of the Mechanical Behavior of Materials, 2014
A recently presented closed-form analytic solution for the displacement field and stress field in a cracked Brazilian disc, under uniform radial pressure along two symmetric arcs of its periphery, revealed that for a wide range of crack-axis inclinations,
Markides Christos F., Pazis Dimitrios N., Kourkoulis Stavros K.   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

An Over-Deterministic Method for Mode III SIF Calculation Using Full-Field Experimental Displacement Fields

Applied Sciences
The paper proposes and tests an approach to determine the stress intensity factors (SIF) of cracks subjected to mode III using full-field displacements as opposed to the crack opening displacement (COD) method, which uses only two data points.
Jorge Guillermo Díaz-Rodríguez, Cesar Hernando Valencia-Niño, Andrés Rodríguez-Torres   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Residual Strength Predictions Based on Two Parameter Fracture Criterion

Hangkong gongcheng jinzhan, 2019
Two parameter fracture criterion is a simple method to predict residual strength. However, some assumptions were taken by the initial derivation process.
Jia Qi
doaj   +1 more source