Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A discussion about a class of stress intensity factors and its verification
, 1991 In this paper, new formulae of a class of stress intensity factors for an infinite plane with two collinear semi-infinite cracks are presented. The formulae differ from those gathered in several handbooks used all over the world.
Zou ZZ, Wang D, Jiang CP, Liu YW
core +2 more sources
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Effect of crack position and size of particle on SIF in SiC particles reinforced Al composite
Fracture and Structural Integrity, 2019 In this paper the effect of reinforcement crack position and loading conditions (in mode I) on the stress intensity factors of the Al/SiCp metal matrix composite was examined using a finite element method.
Aicha Metehri +2 more
doaj +1 more source
Fracture analysis-based mode-I stress intensity factors of crack under fracture grouting in elastic-plastic soils. [PDF]
Sci Rep, 2023 Li L, Deng Y.
europepmc +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Numerical Estimation of Notch Stress Intensity Factors of Sharp V-Notches
MATEC Web of Conferences, 2018 In the present work a simple and efficient least squares method is implemented for accurate estimation of notch stress intensity factors (NSIFs) of sharp V-notches.
Karim Hussain Mirzaul, Murthy K.S.R.K.
doaj +1 more source
Empirical Solution of Stress Intensity Factors for the Inclined Inner Surface Crack of Pipe under External Pressure and Axial Compression. [PDF]
Materials (Basel), 2022 Yao XM +6 more
europepmc +1 more source