Results 91 to 100 of about 1,528,319 (313)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
A cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]
The stress intensity factor is determined for a cracked orthotropic sheet adhesively bonded to an orthotropic stringer. Since the stringer is modeled as a semiinfinite sheet, the solution is most appropriate for a crack tip located near a stringer edge ...
Bigelow, C. A.
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Calibration of NASGRO equation for mixed-mode loading using experimental and numerical data
Revista Facultad de Ingeniería Universidad de Antioquia, 2019 A procedure to calibrate the NASGRO equation in a high yield-strength steel under mixed-mode loading (I+II) is presented. The calibration consists in obtaining the material parameters known as C, m, p and q.
David Reynaldo Berrios-Barcena +2 more
doaj +1 more source
Stress analysis and stress intensity factors for finite geometry solids containing rectangular surface cracks [PDF]
The line method of analysis is applied to the Navier-Cauchy equations of elastic equilibrium to calculate the displacement field in a finite geometry bar containing a variable depth rectangular surface crack under extensionally applied uniform loading ...
Gyekenyesi, J. P., Mendelson, A.
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Stress intensity factors for deep cracks emanating from the corner formed by a hole intersecting a plate surface [PDF]
A technique consisting of freezing photo-elasticity and a numerical method was used to obtain stress intensity factors for natural cracks emanating from the corner at which a hole intersects a plate surface.
Mcgowan, J. J., Smith, C. W.
core +4 more sources
Several intact or broken stringers attached to an orthotropic sheet with a crack [PDF]
Several intact or broken stringers which are continuously attached to a cracked orthotropic sheet through an adhesive are considered. The effect of orthotropy on the stress intensity factors is investigated.
Arin, K.
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source