Results 91 to 100 of about 11,403,302 (291)

Direct Computation of 3-D Stress Intensity Factors of Straight and Curved Planar Cracks with the P-Version Finite Element Method and Contour Integral Method. [PDF]

Materials (Basel), 2021
Zhang J, Xu R, He Y, Yang W.
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Computation of stress intensity factors by the sub-region mixed finite element method of lines

, 2007
Based on the sub-region generalized variational principle, a sub-region mixed version of the newly-developed semi-analytical 'finite element method of lines' (FEMOL) is proposed in this paper for accurate and efficient computation of stress intensity ...
袁驷, 徐永君, Yuan, S (reprint author), Tsing Hua Univ, Dept Civil Engn, Beijing 100084, Peoples R China., Williams FW   +3 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

DETERMINATION OF FRACTURE CHARACTERISTICS FOR LOCAL RIGID PAVEMENT MATERIALS IN IRAQ

Journal of Engineering and Sustainable Development, 2017
This paper presents an experimental method using (TPBT) Three Point Bending Test to identify fracture parameters and performance of concrete rigid pavements such as (KI, KIC, J-Integral and GF).
Zainab Ahmed Alkaissi, Abdulhaq Hadi Ali, Ahmed Abd Ameer   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using of XFEM With Meshing Type-T3 for Orthotropic FGM Plate With A Center Crack Parallel to the Material Gradation Under Fixed Grip Loading

Al-Qadisiyah Journal for Engineering Science, 2015
An improved approach for modeling discrete cracks in two-dimensional anisotropic functional graded materials FGMs by XFEM is described. A general node meshing type-T3 with sub-triangle technique for enhancing the Gauss quadrature accuracy near the crack ...
Hassanein Ibraheem Khalaf, Ameen Ahmed Nassar   +1 more
doaj  

Cracking Characteristics of Different Crack Forms in Pavement under Moving Load

Engineering Transactions
In road engineering, the crack damage problems are one of the essential research areas that need to be emphasized. However, there have been few researches on the effects caused by different crack forms, e.g., the impacts of the distribution and ...
Guannan YAN
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Finite element modeling and experimental studies on mixed mode-I/III fracture specimens

Fracture and Structural Integrity, 2015
In this study, finite element modeling and experimental studies on a mode-I/III specimen similar to the compact tension specimen are presented. By using bolts, the specimen is attached to two loading apparatus that allow different levels of mode-I/III ...
M. Bozkurt, A. O. Ayhan, M. F. Yaren, S. Siriç   +3 more
doaj