Results 91 to 100 of about 588,944 (311)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Fracture Mechanics Investigation of Structures with Defects

open access: yes, 2013
Fracture mechanics plays an important role in the material science, structure design and industrial production due to the failure of materials and structures are paid high attention in human activities.
Li, Yong <1985>
core   +1 more source

Numerical Estimation of Notch Stress Intensity Factors of Sharp V-Notches

open access: yesMATEC Web of Conferences, 2018
In the present work a simple and efficient least squares method is implemented for accurate estimation of notch stress intensity factors (NSIFs) of sharp V-notches.
Karim Hussain Mirzaul, Murthy K.S.R.K.
doaj   +1 more source

Effect of crack position and size of particle on SIF in SiC particles reinforced Al composite

open access: yesFracture and Structural Integrity, 2019
In this paper the effect of reinforcement crack position and loading conditions (in mode I) on the stress intensity factors of the Al/SiCp metal matrix composite was examined using a finite element method.
Aicha Metehri   +2 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

An Over-Deterministic Method for Mode III SIF Calculation Using Full-Field Experimental Displacement Fields

open access: yesApplied Sciences
The paper proposes and tests an approach to determine the stress intensity factors (SIF) of cracks subjected to mode III using full-field displacements as opposed to the crack opening displacement (COD) method, which uses only two data points.
Jorge Guillermo Díaz-Rodríguez   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

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