Results 111 to 120 of about 588,944 (311)
Transient Stress Intensity Factors of an Anti-Plane Crack Propagating in Anisotropic Layered Media
, 2013 The transient analysis of dynamic anti-plane propagation in an anisotropic layered medium is investigated in this study. The complete effects of reflections and diffractions of stress waves that are generated from the interfaces of the anisotropic ...
應宜雄; Ing, Yi-shyong; 莊崇斌; Chuang, Chung-bin
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DETERMINATION OF FRACTURE CHARACTERISTICS FOR LOCAL RIGID PAVEMENT MATERIALS IN IRAQ
Journal of Engineering and Sustainable Development, 2017 This paper presents an experimental method using (TPBT) Three Point Bending Test to identify fracture parameters and performance of concrete rigid pavements such as (KI, KIC, J-Integral and GF).
Zainab Ahmed Alkaissi +2 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
A discussion about a class of stress intensity factors and its verification
, 1991 In this paper, new formulae of a class of stress intensity factors for an infinite plane with two collinear semi-infinite cracks are presented. The formulae differ from those gathered in several handbooks used all over the world.
JIANG, CP (reprint author), CHINESE ACAD SCI,INST MECH,BEIJING 100080,PEOPLES R CHINA. +4 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Analysis of the Stress Intensity Factors and the Shape of a Crack Growth on a Thermal Stress Cleaving [PDF]
, 2006 3D finite element analysis of thermo-elastic problem was performed to relate between the crack front geometry and the crack growing velocity in a thermal stress cleaving.
才本, 明秀 +2 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Journal of Mechanical EngineeringAn elastic isotropic body in a state of plane deformation, which contains a system of randomly placed cracks under the action of a dynamic (harmonic) loading, is considered.
Olha I. Kyrylova, Vsevolod H. Popov
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Сoncentrated force acting near the tip of an interface crack with a rigid overlay on its side
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 Plane stress state near the tip of an interface crack induced by specified concentrated force is considered. One of the crack faces is partially reinforced by a rigid straight line overlay.
Yulia O Vasilyeva, Vasiliy V Silvestrov
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source