Results 111 to 120 of about 1,528,319 (313)
Calculation and Analysis of Crack Stress Intensity Factor and
Jixie chuandong, 2020 The distribution of stress intensity factor and J integral of helical gear with three-dimensional crack under different initial crack parameters is studied. The finite element software is used to analyze the helical gear with initial crack.
Guangyao Sun +2 more
doaj
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Weight Function Method for Stress Intensity Factors of Semi-Elliptical Surface Cracks on Functionally Graded Plates Subjected to Non-Uniform Stresses. [PDF]
Materials (Basel), 2020 Kou KP, Cao JL, Yang Y, Lam CC.
europepmc +1 more source
Stress intensity factor in a tapered specimen [PDF]
The general problem of a tapered specimen containing an edge crack is formulated in terms of a system of singular integral equations. The equations are solved and the stress intensity factor is calculated for a compact and for a slender tapered specimen,
Erdogan, F., Xue-Hui, L.
core +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Stress-Intensity Factors for Corner Cracks at the Edge of a Hole [PDF]
Stress-intensity factors, calculated by a three-dimensional finite-element analysis, for shallow or deep quarter-elliptical corner cracks at the edge of a hole in a finite-thickness plate are presented.
Newman, J. C., Jr., Raju, I. S.
core +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
DETERMINATION OF FRACTURE CHARACTERISTICS FOR LOCAL RIGID PAVEMENT MATERIALS IN IRAQ
Journal of Engineering and Sustainable Development, 2017 This paper presents an experimental method using (TPBT) Three Point Bending Test to identify fracture parameters and performance of concrete rigid pavements such as (KI, KIC, J-Integral and GF).
Zainab Ahmed Alkaissi +2 more
doaj
Shear-stress intensity factors for elastic sheets with cover plates [PDF]
Shear stress intensity factors are calculated for three problems concerning inextensible cover plates either bonded to or embedded in an elastic sheet which is under uniaxial tension.
Fichter, W. B.
core +1 more source