Results 101 to 110 of about 1,528,319 (313)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
The problem of internal and edge cracks in an orthotropic strip [PDF]
The plane elastostatic problem of internal and edge cracks in an infinite orthotropic strip is considered. The problems for the material types 1 and 2 are formulated in terms of singular integral equations.
Delale, F., Erdogan, F.
core +1 more source
Study of the stress intensity factors in the bulk of the material with synchrotron diffraction [PDF]
, 2017 Artículo de Proceedings de Congreso Internacional Fatigue2017In this work we present the results of a hybrid experimental and analytical approach for estimating the stress intensity factor.
Buslaps, T +5 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Stress intensity factors for an inclined crack in an orthotropic strip [PDF]
The elastostatic problem for an infinite orthotropic strip containing a crack is considered. It is assumed that the orthogonal axes of material orthotropy may have an arbitrary angular orientation with respect to the orthogonal axes of geometric symmetry
Bakirtas, I., Delale, F., Erdogan, F.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Three dimensional finite-element analysis of finite-thickness fracture specimens [PDF]
The stress-intensity factors for most of the commonly used fracture specimens (center-crack tension, single and double edge-crack tension, and compact), those that have a through-the-thickness crack, were calculated using a three dimensional finite ...
Newman, J. C., Jr., Raju, I. S.
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Stress intensity factors of composite orthotropic plates containing periodic buffer strips [PDF]
The fracture problem of laminated plates which consist of bonded orthotropic layers is studied. The fields equations for an elastic orthotropic body are transformed to give the displacement and stress expressions for each layer or strip.
Delale, F., Erdogan, F.
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source