Results 121 to 130 of about 1,528,319 (313)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

The crack problem in a specially orthotropic shell with double curvature [PDF]

open access: yes
The crack problem of a shallow shell with two nonzero curvatures is considered. It is assumed that the crack lies in one of the principal planes of curvature and the shell is under Mode I loading condition.
Delale, F., Erdogan, F.
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Accuracy of Determining Stress Intensity Factors in Some Numerical Programs

open access: yesActa Polytechnica, 2001
At present, there are many programs for numerical analysis of cracks, in particular for determining stress intensity factors. Analyses of a single-edge cracked beam and flat plate with a semielliptical surface crack are presented in this study to examine
M. Vorel, E. Leidich
doaj  

Two-dimensional fracture analysis of FGM under mechanical loading

open access: yesJournal of Materials and Engineering Structures, 2020
This paper extends the concept to isotropic functionally graded materials and addresses fracture problems under mechanical loading. The mode-I and mixed mode stress intensity factors (SIFs) are determinate by combination between the finite element method
Imène HEBBAR   +2 more
doaj  

Methods for analysis of cracks in three-dimensional solids [PDF]

open access: yes
Various analytical and numerical methods used to evaluate the stress intensity factors for cracks in three-dimensional (3-D) solids are reviewed. Classical exact solutions and many of the approximate methods used in 3-D analyses of cracks are reviewed ...
Newman, J. C., Jr., Raju, I. S.
core   +1 more source

A failsafe analysis using NASTRAN's piecewise linear analysis and a nine node linear crack element [PDF]

open access: yes, 1975
A two-dimensional crack element was implemented into NASTRAN as a user dummy element and used to study failsafe characteristics of the C5A fuselage. The element is formulated from Reitsner's functional requiring that it satisfy compatability with the ...
Kelley, J. W., Wilkinson, R. F.
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Iterative Method of Determining Stress Intensity Coefficients Under Dynamic Loading of the Crack System

open access: yesJournal of Mechanical Engineering
An elastic isotropic body in a state of plane deformation, which contains a system of randomly placed cracks under the action of a dynamic (harmonic) loading, is considered.
Olha I. Kyrylova, Vsevolod H. Popov
doaj   +1 more source

The crack problem in bonded nonhomogeneous materials [PDF]

open access: yes
The plane elasticity problem for two bonded half planes containing a crack perpendicular to the interface was considered. The effect of very steep variations in the material properties near the diffusion plane on the singular behavior of the stresses and
Erdogan, Fazil   +2 more
core   +1 more source

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