Results 121 to 130 of about 588,944 (311)

Structural integrity of Carbon Dioxide transportation infrastructures

, 2013
Carbon Capture and Storage (CCS) is recognised as having a significant role to play in tackling climate change and reducing carbon dioxide (CO2) emissions.
Zargarzadeh, Payam
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Error estimation of stress intensity factors for mixed-mode cracks

, 2006
This paper presents an a posteriori error estimator for mixed-mode stress intensity factors in plane linear elasticity. A surface integral over an arbitrary crown is used for the separate calculation of the combined mode’s stress intensity factors.
L. Gallimard, Gallimard, L., Panetier, Julien, J. Panetier   +3 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Photoelastic determination of stress intensity factors in patched cracked plates

, 1983
In this paper, the influence of patch parameters on stress intensity factors in edge cracked plates is studied by employing transmission photoelasticity. Edge cracked plates made of photo-elastic material are patched on one side only by E glass-epoxy and
Chandra, R, Subramanian, A, Murthy, MVV, Murthy, MVVS, Rao, AK   +4 more
core   +1 more source

Calculation and Analysis of Crack Stress Intensity Factor and J Integral of Helical Gear

Jixie chuandong, 2020
The distribution of stress intensity factor and J integral of helical gear with three-dimensional crack under different initial crack parameters is studied. The finite element software is used to analyze the helical gear with initial crack.
Guangyao Sun, Mutellip Ahmat, Pengcheng Wang   +2 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stress intensity factors of cracks in straight lug

, 2015
This project aims to determine the stress intensity factors, KI of cracks in straight lug with a hole. These factors are used to predict the crack growth and also the life of structure connected with a straight lug. By using commercially available finite
Lam, Wei Wei
core   +1 more source

Weight Function Method for Stress Intensity Factors of Semi-Elliptical Surface Cracks on Functionally Graded Plates Subjected to Non-Uniform Stresses. [PDF]

Materials (Basel), 2020
Kou KP, Cao JL, Yang Y, Lam CC.
europepmc   +1 more source