Results 61 to 70 of about 1,528,319 (313)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Nihon Kikai Gakkai ronbunshu, 2015 This paper deals with the effect of adhesion layer on the stress intensity factor for small edge interface crack in bonded plates under uniaxial tension or bending.
Kazuhiro ODA +3 more
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Mixed mode stress intensity factors for semielliptical surface cracks [PDF]
The three-dimensional equations of elasticity are solved for a flat elliptical crack which has nonuniform shear stresses applied to its surfaces. An alternating method is used to determine the mode two and mode three stress intensity factors for a ...
Smith, F. W., Sorensen, D. R.
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Elastic stress concentration at radial crossholes in pressurised thick cylinders [PDF]
, 2007 Results of a parametric finite element analysis investigation of stress concentration at radial crossholes in pressurized cylinders are presented in numerical and graphical form.
Comlekci, T. +3 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
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Stress intensity factors in a reinforced thick-walled cylinder [PDF]
An elastic thick-walled cylinder containing a radial crack is considered. It is assumed that the cylinder is reinforced by an elastic membrane on its inner surface. The model is intended to simulate pressure vessels with cladding.
Erdogan, F., Tang, R.
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
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Finite element modeling and experimental studies on mixed mode-I/III fracture specimens
Fracture and Structural Integrity, 2015 In this study, finite element modeling and experimental studies on a mode-I/III specimen similar to the compact tension specimen are presented. By using bolts, the specimen is attached to two loading apparatus that allow different levels of mode-I/III ...
M. Bozkurt +3 more
doaj
A re-evaluation of finite-element models and stress-intensity factors for surface cracks emanating from stress concentrations [PDF]
A re-evaluation of the 3-D finite-element models and methods used to analyze surface crack at stress concentrations is presented. Previous finite-element models used by Raju and Newman for surface and corner cracks at holes were shown to have ill-shaped ...
Newman, J. C., Jr. +3 more
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