Several intact or broken stringers attached to an orthotropic sheet with a crack [PDF]
Several intact or broken stringers which are continuously attached to a cracked orthotropic sheet through an adhesive are considered. The effect of orthotropy on the stress intensity factors is investigated.
Arin, K.
core +1 more source
Dual boundary element method for axisymmetric crack analysis [PDF]
, 2002 In this paper a dual boundary element formulation is developed and applied to the evaluation of stress intensity factors in, and propagation of, axisymmetric cracks.
Lacerda, LA, Wrobel, LC
core
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
A numerical approach for modelling thin cracked plates with XFEM [PDF]
, 2009 The modelization of bending plates with through the thickness cracks is investigated. We consider the Kirchhoff-Love plate model which is valid for very thin plates.
C. Besse +6 more
core +4 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Effect of debond growth on stress-intensity factors in a cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]
Stress-intensity factors are determined for a cracked infinite sheet adhesively bonded to a stringer, and debonding of the adhesive layer is predicted. The stringer is modeled as a semi-infinite sheet. Adhesive nonlinearity is also included.
Bigelow, C. A.
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
On the use of the Peak Stress Method for the calculation of Residual Notch Stress Intensity Factors: a preliminary investigation [PDF]
, 2017 Residual stresses induced by welding processes significantly affect the engineering properties of structural components. If the toe region of a butt-welded joint is modeled as a sharp V-notch, the distribution of the residual stresses in that zone is ...
BERTO, FILIPPO +5 more
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Finite element modeling and experimental studies on mixed mode-I/III fracture specimens
Fracture and Structural Integrity, 2015 In this study, finite element modeling and experimental studies on a mode-I/III specimen similar to the compact tension specimen are presented. By using bolts, the specimen is attached to two loading apparatus that allow different levels of mode-I/III ...
M. Bozkurt +3 more
doaj